ANA, thyroid antibodies, inflammation markers, and rheumatoid screening
The short answer
Autoimmune Advanced Panel bundles 11 tests — Autoimmune Antibody Screen (ANA), Sed Rate (ESR) and Heart & Body Inflammation Test (hs-CRP) plus 8 more — for $159.99 plus one $6 lab processing fee (about $14.54 per test). No fasting is needed; results post in 3–5 business days. Physician-authorized with no doctor's visit or insurance needed; one draw at Quest or Labcorp.
Other Labs
Starting at $350
+ lab fees
TestWell
$159.99
+ $6 lab processing fee
The Autoimmune Advanced Panel screens for the most common autoimmune conditions including lupus (ANA screen with reflex), rheumatoid arthritis (rheumatoid factor, anti-CCP antibodies), Hashimoto's thyroiditis (TPO and thyroglobulin antibodies), and general autoimmune inflammation (ESR, hs-CRP). Ferritin and vitamin D are included because deficiencies in both are strongly associated with autoimmune flares and disease activity. CBC and CMP provide essential baseline context for interpreting autoimmune markers. This panel is ideal for anyone with suspected autoimmune symptoms (joint pain, fatigue, rashes, hair loss) or a family history of autoimmune disease.
Advanced autoimmune workup beyond the basic panel: ANA Screen, anti-dsDNA, anti-Smith, ANCA (P-ANCA + C-ANCA), Rheumatoid Factor, anti-CCP, complement C3/C4, ESR, hs-CRP. Disease-specific diagnosis when basic autoimmune panel is positive.
Anyone with positive ANA on a basic autoimmune workup, suspected systemic lupus (joint pain + rash + fatigue), suspected vasculitis (skin + kidney + lung symptoms), confirming and subtyping connective tissue disease.
Sample Type
Blood draw
Fasting
Not required
Results In
3–5 business days
Biomarkers
39 across 11 tests
11 individual tests · 39 biomarkers measured — each test linked so you can learn more.
No fasting required. No special preparation needed.
What can throw off this result
Physician-reviewed “Before your test” pages — what each factor does, for how long, and what to do about it.
An Autoimmune Advanced Panel costs $159.99 at TestWell — $165.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible.
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Quest or Labcorp) | $159.99 | $165.99 | Includes the one $6 lab processing fee, charged once per order |
Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
ANA Screen, anti-dsDNA (lupus-specific), anti-Smith (lupus-specific), P-ANCA + C-ANCA (vasculitis), Rheumatoid Factor, Anti-CCP, Complement C3 + C4 (immune complex disease), ESR / sed rate, hs-CRP. 10+ tests for disease-specific diagnosis.
Autoimmune Panel at $130 is screening (5 tests: ANA, RF, anti-CCP, hs-CRP, ESR). Autoimmune Advanced at $160 adds disease-specific antibodies (dsDNA, Smith for lupus; ANCA for vasculitis) and complement levels (active immune complex disease marker). Use Advanced when basic panel is positive and you need a specific diagnosis.
Both are highly specific for systemic lupus erythematosus (SLE). Positive anti-dsDNA combined with positive ANA = SLE in most cases (>95% specificity). Positive anti-Smith = SLE definitively (very high specificity, lower sensitivity). Together they confirm or rule out lupus when ANA is positive.
ANCA antibodies suggest small-vessel vasculitis. C-ANCA pattern with anti-PR3 = Granulomatosis with Polyangiitis (formerly Wegener's). P-ANCA pattern with anti-MPO = Microscopic Polyangiitis or Eosinophilic Granulomatosis (Churg-Strauss). Both are urgent diagnoses requiring nephrology + rheumatology involvement.
On TestWell, the Autoimmune Advanced Panel is $159.99. Ordering the same tests separately would be about $250. Quest Direct lists comparable bundles at $350, walk-in hospital labs typically bill $700-1100 without insurance.
No fasting required. Avoid intense exercise for 24 hours before draw — hs-CRP and ESR can be transiently elevated by muscle inflammation.
Order Autoimmune Panel first for unexplained symptoms. Move to Autoimmune Advanced when basic panel is positive (especially ANA) and you need a specific disease diagnosis. Ordering Advanced first is reasonable only with strong clinical suspicion of lupus or vasculitis.
Autoimmune Advanced Panel results are typically ready in 3–5 business days after your draw at Quest or Labcorp. TestWell emails you the moment they post, and your results dashboard shows each marker against its reference range with a plain-English explanation.
Smoking and nicotine, exercise and dehydration can change an Autoimmune Advanced Panel result without anything being wrong. Smoking and nicotine can raise RBC and WBC and 2 more markers on this test and can lower 25-Hydroxy Vitamin D — tell the clinician; a high hematocrit in a smoker is usually smoking, not polycythemia. Exercise can raise ALT and Creatinine and 2 more markers on this test — rest 48 hours before a liver panel. Dehydration can raise BUN and Hemoglobin and 2 more markers on this test — hydrate normally; water is allowed during a fast. Each factor is covered on our physician-reviewed "Before your test" pages; when one applies, the fix is usually to remove it and retest.
Order the Autoimmune Advanced Panel online from TestWell for $159.99 (plus a $6 per-order lab processing fee) — no doctor's visit, referral or insurance needed. A licensed physician authorizes the order, then you walk into any Quest or Labcorp patient service center near you for the draw (the lab locator on our site lists the closest ones by ZIP code), and results arrive in 3–5 business days.
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
Starting at $350 at other labs
TestWell Price
$159.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
Individual tests that complement this panel
Autoimmune Advanced Panel
$159.99