Screen for the most common autoimmune conditions
The short answer
Autoimmune Panel bundles 5 tests — Autoimmune Antibody Screen (ANA), Rheumatoid Factor (RF) and Rheumatoid Arthritis Antibody Test (Anti-CCP) plus 2 more — for $129.99 plus one $6 lab processing fee (about $26.00 per test). No fasting is needed; results post in 3–5 business days. Physician-authorized with no doctor's visit or insurance needed; one draw at Quest or Labcorp.
Other Labs
Starting at $175
+ lab fees
TestWell
$129.99
+ $6 lab processing fee
The Autoimmune Panel combines five key markers to screen for the most common autoimmune conditions. ANA detects antibodies associated with lupus and other connective tissue diseases. Rheumatoid Factor and Anti-CCP target rheumatoid arthritis from two angles — RF for sensitivity and Anti-CCP for specificity. hs-CRP and Sed Rate measure systemic inflammation, which is elevated in most active autoimmune conditions. This panel is ideal for anyone experiencing joint pain, fatigue, rashes, or other unexplained symptoms.
First-line autoimmune workup: ANA Screen, Rheumatoid Factor, Anti-CCP, hs-CRP, ESR. Screens for the major autoimmune disease categories (lupus, RA, Sjögren's, scleroderma) plus inflammation markers.
Anyone with joint pain + swelling lasting >6 weeks, unexplained rashes, recurrent low-grade fevers, family history of autoimmune disease, or multi-system symptoms (fatigue + joint pain + skin changes).
Sample Type
Blood draw
Fasting
Not required
Results In
3–5 business days
Biomarkers
7 across 5 tests
5 individual tests · 7 biomarkers measured — each test linked so you can learn more.
No fasting required. Inform your provider if you are taking immunosuppressive medications.
What can throw off this result
Physician-reviewed “Before your test” pages — what each factor does, for how long, and what to do about it.
An Autoimmune Panel costs $129.99 at TestWell — $135.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible.
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Quest or Labcorp) | $129.99 | $135.99 | Includes the one $6 lab processing fee, charged once per order |
Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
ANA Screen (lupus + connective tissue diseases), Rheumatoid Factor (RA), Anti-CCP (RA specifically — more sensitive than RF), hs-CRP (inflammation), and ESR / sed rate (inflammation). Together they cover the major autoimmune disease categories.
ANA positive (above 1:80 titer) is found in ~15% of healthy adults — most have no autoimmune disease. High titers (>1:320) combined with symptoms or other positive markers (anti-dsDNA, anti-Smith) point to lupus or related conditions. The pattern (homogeneous, speckled, etc.) helps narrow the diagnosis.
Standard Autoimmune Panel: 5 first-line tests for general screening. Autoimmune Advanced Panel at $159 adds disease-specific antibodies (anti-dsDNA, anti-Smith, ANCA, anti-Ro/La, complement levels) — useful when ANA is positive and you need to nail down the specific disease.
On TestWell, the Autoimmune Panel is $129.99. Ordering the same 5 tests separately would be about $170. Quest Direct lists comparable bundles at $175, walk-in hospital labs typically bill $400-600 for the same biomarkers without insurance.
No fasting required. Avoid intense exercise for 24 hours before draw, since both hs-CRP and ESR can be transiently elevated by muscle inflammation.
Many autoimmune diseases (early lupus, axial spondyloarthritis, fibromyalgia) can have normal screening labs. Persistent symptoms warrant rheumatology referral regardless of lab results — clinical exam + imaging + symptom pattern matter as much as labs.
Once for screening if symptoms are unexplained. Repeat positive findings every 6-12 months to track disease activity. Inflammation markers (hs-CRP, ESR) can be retested every 3-6 months to monitor treatment response in known autoimmune disease.
Autoimmune Panel results are typically ready in 3–5 business days after your draw at Quest or Labcorp. TestWell emails you the moment they post, and your results dashboard shows each marker against its reference range with a plain-English explanation.
Exercise, recent illness and smoking and nicotine can change an Autoimmune Panel result without anything being wrong. Exercise can raise hs-CRP — rest 48 hours before an inflammation marker. Recent illness can raise hs-CRP — wait 2 weeks (hs-CRP needs a well baseline). Smoking and nicotine can raise hs-CRP — do not attribute a mildly high CRP to another cause without considering smoking. Each factor is covered on our physician-reviewed "Before your test" pages; when one applies, the fix is usually to remove it and retest.
Order the Autoimmune Panel online from TestWell for $129.99 (plus a $6 per-order lab processing fee) — no doctor's visit, referral or insurance needed. A licensed physician authorizes the order, then you walk into any Quest or Labcorp patient service center near you for the draw (the lab locator on our site lists the closest ones by ZIP code), and results arrive in 3–5 business days.
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
Related guide
ANA Test Results Explained: Titers, Patterns, and What a Positive ANA Means
Starting at $175 at other labs
TestWell Price
$129.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
Individual tests that complement this panel
Autoimmune Panel
$129.99