ANA with reflex, rheumatoid factor and both inflammation markers — the first-line autoimmune work-up
The short answer
Autoimmune Screening Panel bundles 4 tests — Autoimmune Antibody Screen (ANA), Heart & Body Inflammation Test (hs-CRP) and Body Inflammation Test (ESR) plus 1 more — for $86.99 plus one $6 lab processing fee (about $21.75 per test). No fasting is needed; results post in 3–5 business days. Physician-authorized with no doctor's visit or insurance needed; one draw at Quest or Labcorp.
TestWell Price
$86.99
+ $6 lab processing fee
When symptoms suggest an autoimmune condition — joint pain and swelling, a photosensitive rash, unexplained fevers or fatigue, dry eyes and mouth, Raynaud's colour changes — the first blood tests answer two questions: is there systemic inflammation, and are there autoantibodies? This panel measures ESR and high-sensitivity CRP for inflammation, rheumatoid factor for rheumatoid arthritis, and an ANA screen that automatically reflexes to titer, pattern and the specific-antibody panel (anti-dsDNA, Smith, SSA/SSB, RNP, Scl-70, centromere, Jo-1) when positive — so a positive screen leaves with the antibodies that point toward lupus, Sjögren's or scleroderma instead of a second visit. Read the results together: a positive ANA alone is common in healthy people, while positive specific antibodies with raised inflammation markers and symptoms warrant a rheumatology referral. No fasting is needed.
Inflammation and autoimmune biomarkers help identify systemic inflammation, suspected autoimmune disease, and disease activity in known autoimmune conditions.
Adults with persistent joint pain or swelling, unexplained rashes or fevers, dry eyes and mouth, Raynaud's, or a family history of lupus, rheumatoid arthritis or Sjögren's who want the first-line work-up before a specialist visit.
Sample Type
Blood draw
Fasting
Not required
Results In
3–5 business days · typical; varies by lab and draw day
Biomarkers
6 across 4 tests
4 individual tests · 6 biomarkers measured — each test linked so you can learn more.
No fasting required. Avoid vigorous exercise for 24 hours before the draw (it can raise CRP). Tell your clinician about medications — several can cause a positive ANA.
What can throw off this result
Physician-reviewed “Before your test” pages — what each factor does, for how long, and what to do about it.
An Autoimmune Screening Panel costs $86.99 at TestWell — $92.99 all-in, since the $6 lab processing fee is charged once per order and there is no draw or physician fee. With insurance you pay your plan's negotiated rate against your deductible; TestWell's price is fixed before the draw and HSA/FSA-eligible.
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Quest or Labcorp) | $86.99 | $92.99 | Includes the one $6 lab processing fee, charged once per order |
Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
The first-line set is an ANA (antinuclear antibody) screen for the connective-tissue diseases such as lupus, Sjögren's and scleroderma; rheumatoid factor (often with anti-CCP) for rheumatoid arthritis; and the two inflammation markers, ESR and CRP. Depending on symptoms clinicians add anti-CCP, HLA-B27 for spondyloarthritis, celiac antibodies, thyroid antibodies or ANCA. No panel screens for every autoimmune disease — this one covers the conditions behind most joint, skin and fatigue presentations.
Usually less than it sounds. Up to one in five healthy adults has a low-titer positive ANA, and without symptoms or elevated ESR/CRP it is typically monitored rather than treated. The reflexed specific-antibody panel is what adds weight: anti-dsDNA or anti-Smith point strongly to lupus, SSA/SSB to Sjögren's, centromere or Scl-70 to scleroderma. Bring the titer, pattern and specific antibodies to a clinician rather than acting on the screen alone.
The Autoimmune Screening Panel includes 4 individual lab tests, bundled at a single panel price below the cost of ordering each test separately. See the full biomarker list and clinical context on the panel page.
Most Autoimmune Screening Panel results are available in 3–5 business days after your specimen arrives at the lab. You'll get an email the moment results are ready, with everything viewable in your TestWell portal.
Blood draw. A standard venous blood draw, collected at any Quest, Labcorp or BioReference patient service center — walk in with the requisition we email you, no appointment needed at most locations.
On TestWell, the Autoimmune Screening Panel is $86.99. Insurance is not required — pay one all-in price.
No fasting required for the Autoimmune Screening Panel. No fasting required. Avoid vigorous exercise for 24 hours before the draw (it can raise CRP). Tell your clinician about medications — several can cause a positive ANA.
Order online at TestWell — we'll generate a digital requisition and route you to the closest in-network lab. 4,000+ Quest, Labcorp, and BioReference patient service centers nationwide.
Exercise, recent illness and smoking and nicotine can change an Autoimmune Screening Panel result without anything being wrong. Exercise can raise hs-CRP — rest 48 hours before an inflammation marker. Recent illness can raise hs-CRP — wait 2 weeks (hs-CRP needs a well baseline). Smoking and nicotine can raise hs-CRP — do not attribute a mildly high CRP to another cause without considering smoking. Each is explained on our physician-reviewed "Before your test" pages; when one applies, remove it and retest.
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
Related guide
Positive ANA Test: What It Means, Titers, Patterns and What Happens Next
TestWell Price
$86.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
Individual tests that complement this panel
Autoimmune Screening Panel
$86.99