Also known as: Syphilis Test with Confirmation, RPR Test, RPR Blood Test, RPR Syphilis Test, Syphilis Blood Test, RPR with Reflex to Titer
On your lab requisition: Quest “RPR (Diagnosis) with Reflex to Titer and Confirmatory Testing” (test code 36126)BioReference “Syphilis Reverse Algorithm” (test code J275-9)
CPT code: 86592the billing code Quest, Labcorp and hospital labs all use for this test
The short answer
Syphilis Test (RPR with Confirmation) measures RPR Screen and FTA-ABS Confirmation (if reactive) from a standard blood draw. At TestWell it costs $21.99 plus a $6 lab processing fee, needs no fasting, and results post in 2–5 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Quest or Labcorp.
Hospital Lab
$150
cash pay
Other Labs
$52
+ lab fees
TestWell
$21.99
+ $6 lab processing fee
At Quest and Labcorp this test uses an RPR (Rapid Plasma Reagin) screen to detect syphilis antibodies, with a titer and a confirmatory treponemal test performed automatically if the screen is reactive; at BioReference (New York and New Jersey orders) the laboratory runs the reverse algorithm — a treponemal antibody screen first, with reflex to RPR — and either route ends in a confirmed result. Syphilis is a bacterial STI that progresses through stages and can cause serious health problems if untreated, including neurological and cardiovascular damage. Early detection enables simple, effective antibiotic treatment.
Two-step screening for Treponema pallidum (the syphilis bacterium): reactive RPR/VDRL screen triggers automatic FTA-ABS confirmation. Catches active and past infections.
All pregnant women (universal screening), MSM annually, anyone with new partners, anyone diagnosed with another STI, anyone with the classic painless chancre or syphilis rash.
Sample Type
Blood draw
Fasting
Not required
Results In
2–5 business days · typical; varies by lab and draw day
Performed At
Quest or Labcorp
2 biomarkers tested
Your Syphilis Test (RPR with Confirmation) results will include values for each of the 2 biomarkers tested, along with reference ranges. Results are reviewed by a licensed physician before being released to your secure portal.
If any values fall outside the normal range, your report will include guidance on what that may mean and recommended next steps. You'll receive an email notification when your results are ready, typically within 2–5 business days.
Typical reference range layout
Lab reports show where your value sits relative to established reference intervals—your physician interprets this in context for you. Already have results? Analyze them with your AI assistant against our physician-reviewed ranges.
No fasting required. Window period: 3–6 weeks after exposure.
TestWell orders the same Syphilis Test (RPR with Confirmation) the labs run for doctors' offices, so you can walk into any of these labs with our requisition — no doctor's visit, a licensed physician authorizes the order, and most patient service centers take walk-ins. The table shows each lab's own test code, the name printed on the requisition, what the lab charges on its own consumer site, and the price through TestWell at that lab (plus one $6 fee per order).
| Lab | Test code | On the requisition | Lab's own site | Through TestWell |
|---|---|---|---|---|
| Quest Diagnostics | test code 36126 | “RPR (Diagnosis) with Reflex to Titer and Confirmatory Testing” | $52.00 | $21.99 + $6 |
| Labcorp | test no. 006072 | “Syphilis Test (RPR with Confirmation)” | $59.00 | $21.99 + $6 |
| BioReference (New York & New Jersey) | test code J275-9 | “Syphilis Reverse Algorithm” | n/a | $27.99 + $6 |
You choose the lab at checkout; the requisition is written for that lab and arrives by email within minutes. New York and New Jersey orders draw at BioReference. Lab-direct prices are read from the labs' public pages and re-checked regularly.
Where to get it near you: patient service centers by state and city · search by ZIP code
A Syphilis Test (RPR with Confirmation) costs $21.99 at TestWell — $27.99 all-in, since the $6 lab processing fee is charged once per order and there is no draw or physician fee. The labs' own sites list the same test at $52.00 at Quest Health and $59.00 at Labcorp OnDemand (checked Oct 21, 2026). Hospital outpatient labs typically bill around $150.00 self-pay. With insurance you pay your plan's negotiated rate against your deductible; TestWell's price is fixed before the draw and HSA/FSA-eligible. Full cost breakdown →
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Quest or Labcorp) | $21.99 | $27.99 | Includes the one $6 lab processing fee, charged once per order |
| TestWell (drawn at BioReference — New York & New Jersey) | $27.99 | $33.99 | New York and New Jersey orders route to BioReference; Quest Health and Labcorp OnDemand don't take self-ordered draws in those states |
| Quest Health (Quest Diagnostics' own site) | $52.00 | $52.00 | list price checked Oct 21, 2026 |
| Labcorp OnDemand (Labcorp's own site) | $59.00 | $59.00 | list price checked Oct 21, 2026 |
| Hospital outpatient lab, self-pay (typical) | $150.00 | $150.00 | Reference figure; hospital charges vary widely by facility and are often higher |
46% less than the lower lab-direct list price, for the same draw at the same lab. Lab test codes: Quest test code 36126 · Labcorp test no. 006072 · BioReference code J275-9. Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
Two-step process. RPR or VDRL screens first (looks for non-specific anti-cardiolipin antibodies). If reactive, a treponemal-specific confirmatory test (FTA-ABS or TP-PA) runs automatically. This algorithm catches active infection and distinguishes it from false positives.
Tests become reliable 3-6 weeks after exposure. Earlier testing can produce false negatives. If you've had a known exposure within the last 3 weeks and are symptomatic (painless ulcer, rash), see urgent care for clinical evaluation rather than relying on lab tests alone.
RPR titer reported as a ratio (1:1, 1:8, 1:64 — higher titers = more active infection). FTA-ABS or TP-PA reported as reactive/non-reactive. Treated syphilis often shows a positive treponemal test forever (lifelong 'serologic scar') with a negative or low RPR.
On TestWell, the Syphilis Test (RPR with Confirmation) is $21.99. Quest Health lists the same test at $52, walk-in hospital labs typically bill $100-150 without insurance.
RPR screen: CPT 86592. Treponemal confirmation (FTA-ABS): CPT 86780. Both codes appear if the screen reflexes to confirmation.
Yes if you haven't been tested recently. The STI Comprehensive Panel includes syphilis plus HIV, chlamydia & gonorrhea, hepatitis B, and hepatitis C at a discount.
Ordered directly, a Syphilis Test (RPR with Confirmation) lists at $52.00 at Quest Health (Quest Diagnostics' own site) and $59.00 at Labcorp OnDemand (prices checked October 2026). TestWell orders the same test at the same Quest or Labcorp patient service centers for $21.99 — $27.99 all-in with the $6 per-order lab processing fee — paid out of pocket at checkout with no insurance, doctor's visit or draw fee; HSA and FSA cards are accepted.
No, fasting is not required for a Syphilis Test (RPR with Confirmation) — you can eat normally and book any time of day. Window period: 3–6 weeks after exposure.
Order the Syphilis Test (RPR with Confirmation) online from TestWell for $21.99 (plus a $6 per-order lab processing fee) — no doctor's visit, referral or insurance needed. A licensed physician authorizes the order, then you walk into any Quest or Labcorp patient service center near you for the draw (the lab locator on our site lists the closest ones by ZIP code), and results arrive in 2–5 business days.
The Syphilis Test (RPR with Confirmation) is Quest Diagnostics test code 36126 ("RPR (Diagnosis) with Reflex to Titer and Confirmatory Testing"), Labcorp test number 006072, BioReference code J275-9 ("Syphilis Reverse Algorithm") (CPT 86592). TestWell orders it under those codes for $21.99 at Quest, Labcorp or BioReference — no doctor's visit or insurance required, results in 2–5 business days. Codes verified against the labs' catalogs in 2026.
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
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TestWell Price
$21.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
Better value: the STI Comprehensive Panel
Save $68.94This test is part of the STI Comprehensive Panel — 7 tests · 14 biomarkers for $249.99, $68.94 less than à la carte.
$249.99$318.93
7 tests · 14 biomarkers
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Syphilis Test (RPR with Confirmation)
$21.99