Hormones, thyroid, metabolic health, and genetic factors that impact male fertility
The short answer
Men's Complete Fertility & Wellness Panel bundles 21 tests — Estradiol (E2), LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone) plus 18 more — for $349.99 plus one $6 lab processing fee (about $16.67 per test). Fast 8–12 hours before the draw; results post in 3–7 business days. Physician-authorized with no doctor's visit or insurance needed; one draw at Quest or Labcorp.
Other Labs
Starting at $800
+ lab fees
TestWell
$349.99
+ $6 lab processing fee
The Men's Complete Fertility & Wellness Panel evaluates the key hormonal, metabolic, and nutritional factors that impact male reproductive health. It covers reproductive hormones critical for sperm production (total and free testosterone, LH, FSH, prolactin, estradiol, DHEA-S, SHBG), thyroid function including autoimmune markers (TSH, free T3, free T4, reverse T3, TPO antibodies), metabolic factors that affect sperm quality (CMP, fasting insulin, HbA1c), essential nutrients linked to fertility (vitamin D, B12, ferritin, homocysteine), and MTHFR gene mutation analysis which affects folate metabolism and DNA integrity in sperm.
Comprehensive 21-marker men's fertility and wellness workup: reproductive hormones (Total + Free Testosterone, DHEA-S, SHBG, Estradiol, LH, FSH, Prolactin); full thyroid with autoimmune markers (TSH, Free T3, Free T4, Reverse T3, TPO Antibodies); metabolic health (CMP, Fasting Insulin, HbA1c); nutrients tied to fertility (Vitamin D, B12, Ferritin, Homocysteine); and MTHFR genetic testing. Identifies the hormonal, metabolic, and pituitary causes of male-factor infertility.
Men trying to conceive for 6+ months without success, men with prior infertility evaluation showing abnormal semen analysis, men considering testicular biopsy or IVF, anyone evaluating low testosterone with fertility concerns.
Sample Type
Blood draw
Fasting
Required
Results In
3–7 business days
Biomarkers
35 across 21 tests
21 individual tests · 35 biomarkers measured — each test linked so you can learn more.
Fasting for 10–12 hours is recommended. Morning blood draw (before 10 AM) preferred for accurate testosterone and hormone levels.
What can throw off this result
Physician-reviewed “Before your test” pages — what each factor does, for how long, and what to do about it.
A Men's Complete Fertility & Wellness Panel costs $349.99 at TestWell — $355.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible.
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Quest or Labcorp) | $349.99 | $355.99 | Includes the one $6 lab processing fee, charged once per order |
Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
21 markers. Reproductive hormones: Total Testosterone, Free Testosterone, DHEA-S, SHBG, Estradiol, LH, FSH, Prolactin. Full thyroid with autoimmune markers: TSH, Free T3, Free T4, Reverse T3, TPO Antibodies. Metabolic health that affects sperm quality: CMP, Fasting Insulin, HbA1c. Nutrients tied to fertility: Vitamin D, B12, Ferritin, Homocysteine, plus MTHFR genetic testing. (Semen analysis is separate and not a blood test.)
Confirm with two morning draws. If primary failure (high FSH/LH), TRT may help but suppresses fertility further — discuss with a urologist before starting. If secondary (low FSH/LH), MRI to rule out pituitary tumor; treatment is usually clomiphene or hCG injections (fertility-preserving) rather than TRT.
On TestWell, the Men's Complete Fertility & Wellness Panel is $349.99. Ordering the same tests separately would be about $470. Quest Direct lists comparable bundles at $800, walk-in hospital labs and fertility clinics typically bill $1500-3000 without insurance.
No — semen analysis requires specialized collection and cannot be done from a blood draw. Get it at a fertility clinic or urology office. The blood panel evaluates hormonal causes; semen analysis evaluates sperm quality directly. Both are usually needed for complete male-factor workup.
Yes — 9-12 hours fasting (water only) and morning draw (7-10 AM) for accurate testosterone and prolactin results. Avoid intense exercise 24 hours before.
Yes — 50% of infertility involves a female factor. Pair this with our Women's Complete Fertility & Wellness Panel for a complete couples' workup.
Men's Complete Fertility & Wellness Panel results are typically ready in 3–7 business days after your draw at Quest or Labcorp. TestWell emails you the moment they post, and your results dashboard shows each marker against its reference range with a plain-English explanation.
Common medications, oral contraceptives and estrogen and biotin supplements can change a Men's Complete Fertility & Wellness Panel result without anything being wrong. Common medications can raise ALT, SHBG and Glucose and can lower Total Testosterone and Vitamin B12 — continue; report muscle pain to the prescriber. Oral contraceptives and estrogen can raise SHBG, Free T3 and Ferritin and can lower Total Testosterone and Estradiol — expected; interpret testosterone with it. Biotin supplements can falsely lower TSH and can falsely raise Free T3 and 25-Hydroxy Vitamin D — stop biotin ≥72 hours before the draw. Each factor is covered on our physician-reviewed "Before your test" pages; when one applies, the fix is usually to remove it and retest.
Order the Men's Complete Fertility & Wellness Panel online from TestWell for $349.99 (plus a $6 per-order lab processing fee) — no doctor's visit, referral or insurance needed. A licensed physician authorizes the order, then you walk into any Quest or Labcorp patient service center near you for the draw (the lab locator on our site lists the closest ones by ZIP code), and results arrive in 3–7 business days.
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
Starting at $800 at other labs
TestWell Price
$349.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
Individual tests that complement this panel
Men's Complete Fertility & Wellness Panel
$349.99