The short answer
MTHFR Gene Mutation Analysis measures MTHFR C677T and MTHFR A1298C from a standard blood draw. At TestWell it costs $95.99 plus a $6 lab fee, needs no fasting, and results post in 5–7 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Labcorp.
Hospital Lab
$400
cash pay
Other Labs
$149
+ lab fees
TestWell
$95.99
+ $6 lab fee
The MTHFR gene provides instructions for making an enzyme that processes folate (vitamin B9) and regulates homocysteine levels. Variants C677T and A1298C can reduce enzyme activity by 30–70%, potentially leading to elevated homocysteine, impaired methylation, and increased risk for cardiovascular disease, neural tube defects, and recurrent pregnancy loss. This test is frequently ordered for patients with unexplained elevated homocysteine, a family history of blood clots, or recurrent miscarriages. Results can guide supplementation with methylated folate (L-methylfolate) instead of standard folic acid.
Genetic test for the C677T and A1298C variants in the MTHFR gene — variants that reduce folate-cycle enzyme activity by 30-70%. Common (10-15% of population homozygous).
Anyone with elevated homocysteine, recurrent miscarriage, family history of clotting disorders, methylation-focused wellness optimization, or planning pregnancy with elevated risk factors.
Sample Type
Blood draw
Fasting
Not required
Results In
5–7 business days
Performed At
Labcorp
2 biomarkers tested
Your MTHFR Gene Mutation Analysis results will include values for each of the 2 biomarkers tested, along with reference ranges. Results are reviewed by a licensed physician before being released to your secure portal.
If any values fall outside the normal range, your report will include guidance on what that may mean and recommended next steps. You'll receive an email notification when your results are ready, typically within 5–7 business days.
Typical reference range layout
Lab reports show where your value sits relative to established reference intervals—your physician interprets this in context for you.
No fasting or special preparation required.
A MTHFR Gene Mutation Analysis test costs $95.99 at TestWell — $101.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. Hospital outpatient labs typically bill around $400.00 self-pay for the same test, and often more. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible.
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Quest or Labcorp) | $95.99 | $101.99 | Includes the one $6 lab processing fee, charged once per order |
| Hospital outpatient lab, self-pay (typical) | $400.00 | $400.00 | Reference figure; hospital charges vary widely by facility and are often higher |
Lab test codes: Quest test code 17911 · Labcorp test no. 511238. Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
TestWell Price
$95.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
Better value: the Genetic Risk Panel
Save $61.98This test is part of the Genetic Risk Panel — 3 tests · 4 biomarkers for $299.99, $61.98 less than à la carte.
$299.99$361.97
3 tests · 4 biomarkers
Frequently ordered together
Customers who ordered MTHFR Gene Mutation Analysis also added these for a more complete health picture.
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MTHFR Gene Mutation Analysis
$95.99