On your lab requisition: Quest “Methylenetetrahydrofolate Reductase (MTHFR), DNA Mutation Analysis” (test code 17911)
The short answer
MTHFR Gene Mutation Analysis measures MTHFR C677T and MTHFR A1298C from a standard blood draw. At TestWell it costs $95.99 plus a $6 lab processing fee, needs no fasting, and results post in 5–7 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Labcorp.
Hospital Lab
$400
cash pay
Other Labs
$149
+ lab fees
TestWell
$95.99
+ $6 lab processing fee
The MTHFR gene provides instructions for making an enzyme that processes folate (vitamin B9) and regulates homocysteine levels. Variants C677T and A1298C can reduce enzyme activity by 30–70%, potentially leading to elevated homocysteine, impaired methylation, and increased risk for cardiovascular disease, neural tube defects, and recurrent pregnancy loss. This test is frequently ordered for patients with unexplained elevated homocysteine, a family history of blood clots, or recurrent miscarriages. Results can guide supplementation with methylated folate (L-methylfolate) instead of standard folic acid.
Genetic test for the C677T and A1298C variants in the MTHFR gene — variants that reduce folate-cycle enzyme activity by 30-70%. Common (10-15% of population homozygous).
Anyone with elevated homocysteine, recurrent miscarriage, family history of clotting disorders, methylation-focused wellness optimization, or planning pregnancy with elevated risk factors.
Sample Type
Blood draw
Fasting
Not required
Results In
5–7 business days
Performed At
Labcorp
2 biomarkers tested
Your MTHFR Gene Mutation Analysis results will include values for each of the 2 biomarkers tested, along with reference ranges. Results are reviewed by a licensed physician before being released to your secure portal.
If any values fall outside the normal range, your report will include guidance on what that may mean and recommended next steps. You'll receive an email notification when your results are ready, typically within 5–7 business days.
Typical reference range layout
Lab reports show where your value sits relative to established reference intervals—your physician interprets this in context for you. Already have results? Analyze them with your AI assistant against our physician-reviewed ranges.
No fasting or special preparation required.
An MTHFR Gene Mutation Analysis test costs $95.99 at TestWell — $101.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. Hospital outpatient labs typically bill around $400.00 self-pay for the same test, and often more. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible.
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Labcorp) | $95.99 | $101.99 | Includes the one $6 lab processing fee, charged once per order |
| Hospital outpatient lab, self-pay (typical) | $400.00 | $400.00 | Reference figure; hospital charges vary widely by facility and are often higher |
Lab test codes: Quest test code 17911 · Labcorp test no. 511238. Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
Mixed evidence. ACMG/ACOG don't recommend routine MTHFR testing because homozygous variants are common (10-15% of people) and rarely cause clinical disease on their own. It's useful when paired with elevated homocysteine, recurrent miscarriage, or family clotting history.
TestWell charges $95.99 — vs $179 at Quest Direct and $250-$500 at genetics clinics. Result is genetic — test once for life.
Most people with MTHFR variants don't need anything special — a typical diet provides enough folate. If you have elevated homocysteine (>10 mcmol/L), 5-MTHF (methylfolate) plus B12 can help normalize it. Pair this test with Homocysteine for actionable insight.
MTHFR Gene Mutation Analysis test results are typically ready in 5–7 business days after your draw at Labcorp. TestWell emails you the moment they post, and your results dashboard shows each marker against its reference range with a plain-English explanation.
No, fasting is not required for an MTHFR Gene Mutation Analysis test — you can eat normally and book any time of day. No fasting or special preparation required.
Order the MTHFR Gene Mutation Analysis test online from TestWell for $95.99 (plus a $6 per-order lab processing fee) — no doctor's visit, referral or insurance needed. A licensed physician authorizes the order, then you walk into any Labcorp patient service center near you for the draw (the lab locator on our site lists the closest ones by ZIP code), and results arrive in 5–7 business days.
The CPT code for an MTHFR Gene Mutation Analysis test is 81291. You can order it from TestWell for $95.99 — no doctor's visit or insurance required, with results in 5–7 business days.
The MTHFR Gene Mutation Analysis test is Quest Diagnostics test code 17911 ("Methylenetetrahydrofolate Reductase (MTHFR), DNA Mutation Analysis"), Labcorp test number 511238 (CPT 81291). TestWell orders it under those codes for $95.99 at Quest or Labcorp — no doctor's visit or insurance required, results in 5–7 business days. Codes verified against the labs' catalogs in 2026.
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
TestWell Price
$95.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
Better value: the Genetic Risk Panel
Save $61.98This test is part of the Genetic Risk Panel — 3 tests · 4 biomarkers for $299.99, $61.98 less than à la carte.
$299.99$361.97
3 tests · 4 biomarkers
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MTHFR Gene Mutation Analysis
$95.99