Also known as: ApoE Alzheimer's Risk
On your lab requisition: Labcorp “APOE Alzheimer's Disease Risk” (test no. 125536)
The short answer
Screens for ApoE4 gene variant — the strongest known genetic risk factor for late-onset Alzheimer's disease, measured from a standard blood draw. At TestWell it costs $184.99 plus a $6 lab processing fee, needs no fasting, and results post in 5–7 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Labcorp.
Hospital Lab
$600
cash pay
Other Labs
$249
+ lab fees
TestWell
$184.99
+ $6 lab processing fee
The ApoE4 variant is the most significant known genetic risk factor for late-onset Alzheimer's disease. Carrying one copy of E4 increases risk 3–4x, while two copies increase risk 8–12x compared to the most common E3/E3 genotype. This test identifies your specific ApoE genotype and its associated Alzheimer's risk. It is important to understand that ApoE4 is a risk factor, not a diagnosis — many E4 carriers never develop Alzheimer's, and many Alzheimer's patients do not carry E4. Results should be discussed with a healthcare provider and may inform lifestyle interventions that reduce risk.
Genotypes the APOE gene (ε2, ε3, ε4 alleles) from a blood sample. One ε4 copy raises lifetime late-onset Alzheimer's risk roughly 3-fold and two copies 8- to 12-fold versus the common ε3/ε3 genotype; ε2 is modestly protective. It is a risk marker, not a diagnosis — many ε4 carriers never develop dementia and many patients with Alzheimer's carry no ε4.
Adults with a parent or sibling diagnosed with Alzheimer's who want to know their genetic risk, people planning long-term brain-health, lipid or lifestyle strategies (ε4 also affects LDL cholesterol and cardiovascular risk), and anyone considering or already on an anti-amyloid therapy, where APOE status changes the side-effect risk. Consider genetic counseling before and after testing.
Sample Type
Blood draw
Fasting
Not required
Results In
5–7 business days · typical; varies by lab and draw day
Performed At
Labcorp
1 biomarker tested
Your ApoE Alzheimer's Risk results will include values for each of the 1 biomarker tested, along with reference ranges. Results are reviewed by a licensed physician before being released to your secure portal.
If any values fall outside the normal range, your report will include guidance on what that may mean and recommended next steps. You'll receive an email notification when your results are ready, typically within 5–7 business days.
Typical reference range layout
Lab reports show where your value sits relative to established reference intervals—your physician interprets this in context for you. Already have results? Analyze them with your AI assistant against our physician-reviewed ranges.
No fasting or special preparation required.
TestWell orders the same ApoE Alzheimer's Risk the labs run for doctors' offices, so you can walk into Labcorp with our requisition — no doctor's visit, a licensed physician authorizes the order, and most patient service centers take walk-ins. The table shows each lab's own test code, the name printed on the requisition, what the lab charges on its own consumer site, and the price through TestWell at that lab (plus one $6 fee per order).
| Lab | Test code | On the requisition | Lab's own site | Through TestWell |
|---|---|---|---|---|
| Labcorp | test no. 125536 | “APOE Alzheimer's Disease Risk” | not sold direct | $184.99 + $6 |
You choose the lab at checkout; the requisition is written for that lab and arrives by email within minutes. New York and New Jersey orders draw at BioReference. Lab-direct prices are read from the labs' public pages and re-checked regularly.
Where to get it near you: patient service centers by state and city · search by ZIP code
An ApoE Alzheimer's Risk test costs $184.99 at TestWell — $190.99 all-in, since the $6 lab processing fee is charged once per order and there is no draw or physician fee. Hospital outpatient labs typically bill around $600.00 self-pay. With insurance you pay your plan's negotiated rate against your deductible; TestWell's price is fixed before the draw and HSA/FSA-eligible.
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Labcorp) | $184.99 | $190.99 | Includes the one $6 lab processing fee, charged once per order |
| Hospital outpatient lab, self-pay (typical) | $600.00 | $600.00 | Reference figure; hospital charges vary widely by facility and are often higher |
Lab test codes: Labcorp test no. 125536. Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
On TestWell the ApoE genotype test is $184.99 (plus a $6 lab processing fee), drawn at a Labcorp patient service center with results in 5–7 business days. Quest Health lists comparable ApoE testing at about $249, and genetic testing ordered through a neurology or memory clinic is typically billed at $600 or more before insurance. Consumer saliva DNA kits report APOE status inside a broader health report for roughly $200 but take several weeks and are not a clinical-grade result you can hand to a physician. Insurance rarely covers APOE testing in people without symptoms.
Your result is a genotype — ε3/ε3 (most common, baseline risk), ε3/ε4 or ε2/ε4 (one ε4 copy, roughly three times the baseline lifetime risk), ε4/ε4 (two copies, roughly 8–12 times), or ε2/ε3 and ε2/ε2 (modestly below baseline). About one in four people carry at least one ε4. Risk is not destiny: most single-copy carriers never develop Alzheimer's, and the modifiable factors — blood pressure, LDL cholesterol, blood sugar, sleep, hearing, exercise — matter more for carriers, not less.
Medical guidelines don't recommend APOE testing for everyone, because there is no treatment that changes based on the result alone. People choose it to inform lifestyle decisions, to understand a family pattern, before starting anti-amyloid drugs (two ε4 copies raise the risk of brain swelling and bleeding with those medications), or for peace of mind. Think in advance about how you'd feel about each result, and consider a genetic counselor — many offer a single telehealth session.
In the US the Genetic Information Nondiscrimination Act (GINA) bars health insurers and employers from using genetic results against you. GINA does not cover life, disability or long-term-care insurance, whose applications can ask about genetic testing. Results ordered through TestWell go only to you and the reviewing physician; nothing is reported to insurers.
A standard blood draw at Labcorp — no fasting, no special preparation. The genotype is determined by DNA analysis, so it never changes and never needs repeating. The CPT code is 81401.
Yes. ε4 carriers tend to have higher LDL cholesterol and absorb dietary cholesterol more efficiently, and ε4 is associated with modestly higher cardiovascular risk. Many people pair this test with a lipid panel or ApoB to act on the part of the risk that is treatable today.
ApoE Alzheimer's Risk test results are typically ready in 5–7 business days after your draw at Labcorp. TestWell emails you the moment they post, and your results dashboard shows each marker against its reference range with a plain-English explanation.
No, fasting is not required for an ApoE Alzheimer's Risk test — you can eat normally and book any time of day. No fasting or special preparation required.
Order the ApoE Alzheimer's Risk test online from TestWell for $184.99 (plus a $6 per-order lab processing fee) — no doctor's visit, referral or insurance needed. A licensed physician authorizes the order, then you walk into any Labcorp patient service center near you for the draw (the lab locator on our site lists the closest ones by ZIP code), and results arrive in 5–7 business days.
The ApoE Alzheimer's Risk test is Labcorp test number 125536 ("APOE Alzheimer's Disease Risk"). TestWell orders it under that code for $184.99 at Labcorp — no doctor's visit or insurance required, results in 5–7 business days. Codes verified against the labs' catalogs in 2026.
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
Related guide
How Much Does an APOE Test Cost? Alzheimer's Genetic Testing Prices at a Lab, a Consumer DNA Kit or a Genetics Clinic — and What the Result Can Tell You
TestWell Price
$184.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
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