The short answer
Tests for the most common inherited blood clotting disorder — increases risk of deep vein thrombosis and pulmonary embolism, measured from a standard blood draw. At TestWell it costs $131.99 plus a $6 lab fee, needs no fasting, and results post in 5–7 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Quest or Labcorp.
Hospital Lab
$450
cash pay
Other Labs
$175
+ lab fees
TestWell
$131.99
+ $6 lab fee
Factor V Leiden is the most common inherited thrombophilia (blood clotting disorder), affecting approximately 5% of Caucasians. The mutation makes Factor V resistant to inactivation by Activated Protein C, leading to increased clot formation. Heterozygous carriers (one copy) have a 3–8x increased risk of venous thromboembolism (VTE), while homozygous carriers (two copies) have a 50–80x increased risk. This test is recommended for individuals with a personal or family history of blood clots (DVT, pulmonary embolism), unexplained recurrent pregnancy loss, or clots at a young age. Results inform decisions about anticoagulation therapy, hormone use, and surgical precautions.
Genetic test for the Factor V Leiden mutation — the most common inherited cause of abnormal blood clotting. Present in 3-8% of people of European descent.
Anyone with a personal or family history of DVT/PE, recurrent miscarriage, stroke under 50, women considering combined oral contraceptives or HRT with a clotting history, or post-thrombosis evaluation.
Sample Type
Blood draw
Fasting
Not required
Results In
5–7 business days
Performed At
Quest or Labcorp
1 biomarker tested
Your Factor V Leiden Mutation results will include values for each of the 1 biomarker tested, along with reference ranges. Results are reviewed by a licensed physician before being released to your secure portal.
If any values fall outside the normal range, your report will include guidance on what that may mean and recommended next steps. You'll receive an email notification when your results are ready, typically within 5–7 business days.
Typical reference range layout
Lab reports show where your value sits relative to established reference intervals—your physician interprets this in context for you.
No fasting or special preparation required.
A Factor V Leiden Mutation test costs $131.99 at TestWell — $137.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. Hospital outpatient labs typically bill around $450.00 self-pay for the same test, and often more. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible.
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Quest or Labcorp) | $131.99 | $137.99 | Includes the one $6 lab processing fee, charged once per order |
| Hospital outpatient lab, self-pay (typical) | $450.00 | $450.00 | Reference figure; hospital charges vary widely by facility and are often higher |
Lab test codes: Quest test code 17900 · Labcorp test no. 511154. Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
TestWell Price
$131.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
Better value: the Blood Clotting Panel
Save $50.97This test is part of the Blood Clotting Panel — 4 tests · 18 biomarkers for $149.99, $50.97 less than à la carte.
$149.99$200.96
4 tests · 18 biomarkers
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Factor V Leiden Mutation
$131.99