On your lab requisition: Quest “Factor V (Leiden) Mutation Analysis” (test code 17900)
The short answer
Tests for the most common inherited blood clotting disorder — increases risk of deep vein thrombosis and pulmonary embolism, measured from a standard blood draw. At TestWell it costs $131.99 plus a $6 lab processing fee, needs no fasting, and results post in 5–7 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Quest or Labcorp.
Hospital Lab
$450
cash pay
Other Labs
$175
+ lab fees
TestWell
$131.99
+ $6 lab processing fee
Factor V Leiden is the most common inherited thrombophilia (blood clotting disorder), affecting approximately 5% of Caucasians. The mutation makes Factor V resistant to inactivation by Activated Protein C, leading to increased clot formation. Heterozygous carriers (one copy) have a 3–8x increased risk of venous thromboembolism (VTE), while homozygous carriers (two copies) have a 50–80x increased risk. This test is recommended for individuals with a personal or family history of blood clots (DVT, pulmonary embolism), unexplained recurrent pregnancy loss, or clots at a young age. Results inform decisions about anticoagulation therapy, hormone use, and surgical precautions.
Genetic test for the Factor V Leiden mutation — the most common inherited cause of abnormal blood clotting. Present in 3-8% of people of European descent.
Anyone with a personal or family history of DVT/PE, recurrent miscarriage, stroke under 50, women considering combined oral contraceptives or HRT with a clotting history, or post-thrombosis evaluation.
Sample Type
Blood draw
Fasting
Not required
Results In
5–7 business days
Performed At
Quest or Labcorp
1 biomarker tested
Your Factor V Leiden Mutation results will include values for each of the 1 biomarker tested, along with reference ranges. Results are reviewed by a licensed physician before being released to your secure portal.
If any values fall outside the normal range, your report will include guidance on what that may mean and recommended next steps. You'll receive an email notification when your results are ready, typically within 5–7 business days.
Typical reference range layout
Lab reports show where your value sits relative to established reference intervals—your physician interprets this in context for you. Already have results? Analyze them with your AI assistant against our physician-reviewed ranges.
No fasting or special preparation required.
A Factor V Leiden Mutation test costs $131.99 at TestWell — $137.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. Hospital outpatient labs typically bill around $450.00 self-pay for the same test, and often more. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible.
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Quest) | $131.99 | $137.99 | Includes the one $6 lab processing fee, charged once per order |
| TestWell (drawn at Labcorp) | $159.99 | $165.99 | Labcorp's own cost for this test is higher; same order, same portal, same physician review |
| Hospital outpatient lab, self-pay (typical) | $450.00 | $450.00 | Reference figure; hospital charges vary widely by facility and are often higher |
Lab test codes: Quest test code 17900 · Labcorp test no. 511154. Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
A single-letter DNA mutation in the F5 gene that makes Factor V resistant to inactivation — so clots form more easily. Heterozygous carriers have a 3-8× higher lifetime risk of DVT; homozygous carriers 30-80× higher.
TestWell charges $131.99 — vs $179 at Quest Direct and $300-$600 at hospital genetics clinics.
No fasting required and you only need to test once — the result is genetic and doesn't change.
Routine pre-pill screening isn't recommended unless you have personal or family clotting history, because combined hormonal contraceptives raise DVT risk 2-4× on their own — and 30-50× in Factor V Leiden carriers. With a clotting family history, get tested before starting.
Most carriers never have a clot. The diagnosis informs decisions: avoid estrogen-containing contraceptives, careful clotting prophylaxis during/after surgery, pregnancy management plans, and stop smoking. Anticoagulation isn't prescribed prophylactically without a clotting event.
Factor V Leiden Mutation test results are typically ready in 5–7 business days after your draw at Quest or Labcorp. TestWell emails you the moment they post, and your results dashboard shows each marker against its reference range with a plain-English explanation.
Order the Factor V Leiden Mutation test online from TestWell for $131.99 (plus a $6 per-order lab processing fee) — no doctor's visit, referral or insurance needed. A licensed physician authorizes the order, then you walk into any Quest or Labcorp patient service center near you for the draw (the lab locator on our site lists the closest ones by ZIP code), and results arrive in 5–7 business days.
The CPT code for a Factor V Leiden Mutation test is 81241. You can order it from TestWell for $131.99 — no doctor's visit or insurance required, with results in 5–7 business days.
The Factor V Leiden Mutation test is Quest Diagnostics test code 17900 ("Factor V (Leiden) Mutation Analysis"), Labcorp test number 511154 (CPT 81241). TestWell orders it under those codes for $131.99 at Quest or Labcorp — no doctor's visit or insurance required, results in 5–7 business days. Codes verified against the labs' catalogs in 2026.
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
TestWell Price
$131.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
Better value: the Blood Clotting Panel
Save $50.97This test is part of the Blood Clotting Panel — 4 tests · 18 biomarkers for $149.99, $50.97 less than à la carte.
$149.99$200.96
4 tests · 18 biomarkers
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Factor V Leiden Mutation
$131.99