On your lab requisition: Quest “Cardio IQ APOE Genotype” (test code 90649)Labcorp “Apo E Genotyping: Cardio Risk” (test no. 503935)
The short answer
Identifies your ApoE genotype (E2, E3, E4) to assess genetic cardiovascular and cholesterol risk, measured from a standard blood draw. At TestWell it costs $133.99 plus a $6 lab processing fee, needs no fasting, and results post in 5–7 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Quest or Labcorp.
Hospital Lab
$500
cash pay
Other Labs
$199
+ lab fees
TestWell
$133.99
+ $6 lab processing fee
Apolipoprotein E (ApoE) is a protein involved in cholesterol transport and metabolism. The three common variants — E2, E3, and E4 — influence how your body processes dietary fat and cholesterol. The E4 variant is associated with higher LDL cholesterol, increased cardiovascular risk, and a stronger response to dietary saturated fat. The E2 variant is associated with lower LDL but can increase triglycerides. Knowing your ApoE genotype helps personalize dietary and lifestyle recommendations for heart health and can inform statin therapy decisions.
ApoE genotype — identifies which of three E2/E3/E4 alleles you carry. ApoE4 carriers have a 2-3× lifetime risk of coronary heart disease and Alzheimer's; ApoE2 carriers have lower CHD risk but higher type III hyperlipoproteinemia risk.
Anyone with strong family history of early heart disease or Alzheimer's, established hyperlipidemia not responding to statins, or planning a precision-medicine cardiovascular prevention strategy.
Sample Type
Blood draw
Fasting
Not required
Results In
5–7 business days
Performed At
Quest or Labcorp
1 biomarker tested
Your ApoE Genotype (Cardiovascular Risk) results will include values for each of the 1 biomarker tested, along with reference ranges. Results are reviewed by a licensed physician before being released to your secure portal.
If any values fall outside the normal range, your report will include guidance on what that may mean and recommended next steps. You'll receive an email notification when your results are ready, typically within 5–7 business days.
Typical reference range layout
Lab reports show where your value sits relative to established reference intervals—your physician interprets this in context for you. Already have results? Analyze them with your AI assistant against our physician-reviewed ranges.
No fasting or special preparation required.
An ApoE Genotype (Cardiovascular Risk) test costs $133.99 at TestWell — $139.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. Hospital outpatient labs typically bill around $500.00 self-pay for the same test, and often more. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible.
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Quest or Labcorp) | $133.99 | $139.99 | Includes the one $6 lab processing fee, charged once per order |
| Hospital outpatient lab, self-pay (typical) | $500.00 | $500.00 | Reference figure; hospital charges vary widely by facility and are often higher |
Lab test codes: Quest test code 90649 · Labcorp test no. 503935. Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
Roughly 25% of people carry one ApoE4 allele (E3/E4); 2-3% carry two (E4/E4). One copy: ~2-3× heart disease risk, ~3× Alzheimer's risk. Two copies: ~5× heart disease, ~12-15× Alzheimer's. Lifestyle and statin therapy substantially mitigate risk — knowing the result enables proactive prevention.
TestWell charges $133.99 — vs $199 at Quest Direct and $300-$700 at genetics or cardiology clinics. One-time test, result is permanent.
81401 (ApoE genotype). HSA/FSA eligible.
Discuss with a clinician first — there's no cure for Alzheimer's, so the result can produce psychological harm without changing treatment. Some carriers want the information to plan; others don't. Genetic counseling is recommended before testing for Alzheimer's risk.
ApoE Genotype (Cardiovascular Risk) test results are typically ready in 5–7 business days after your draw at Quest or Labcorp. TestWell emails you the moment they post, and your results dashboard shows each marker against its reference range with a plain-English explanation.
No, fasting is not required for an ApoE Genotype (Cardiovascular Risk) test — you can eat normally and book any time of day. No fasting or special preparation required.
Order the ApoE Genotype (Cardiovascular Risk) test online from TestWell for $133.99 (plus a $6 per-order lab processing fee) — no doctor's visit, referral or insurance needed. A licensed physician authorizes the order, then you walk into any Quest or Labcorp patient service center near you for the draw (the lab locator on our site lists the closest ones by ZIP code), and results arrive in 5–7 business days.
The ApoE Genotype (Cardiovascular Risk) test is Quest Diagnostics test code 90649 ("Cardio IQ APOE Genotype"), Labcorp test number 503935 ("Apo E Genotyping: Cardio Risk"). TestWell orders it under those codes for $133.99 at Quest or Labcorp — no doctor's visit or insurance required, results in 5–7 business days. Codes verified against the labs' catalogs in 2026.
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
TestWell Price
$133.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
Better value: the Genetic Risk Panel
Save $61.98This test is part of the Genetic Risk Panel — 3 tests · 4 biomarkers for $299.99, $61.98 less than à la carte.
$299.99$361.97
3 tests · 4 biomarkers
Frequently ordered together
Customers who ordered ApoE Genotype (Cardiovascular Risk) also added these for a more complete health picture.
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ApoE Genotype (Cardiovascular Risk)
$133.99