The short answer
Screens for mast cell disorders and anaphylaxis risk — elevated in mastocytosis and after severe allergic reactions, measured from a standard blood draw. At TestWell it costs $71.99 plus a $6 lab fee, needs no fasting, and results post in 3–5 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Quest.
Hospital Lab
$300
cash pay
Other Labs
$99
+ lab fees
TestWell
$71.99
+ $6 lab fee
Tryptase is an enzyme released primarily by mast cells. Baseline tryptase levels are used to screen for mastocytosis (an abnormal accumulation of mast cells) and mast cell activation syndrome (MCAS) — conditions that cause flushing, hives, gastrointestinal symptoms, and potentially life-threatening anaphylaxis. A baseline tryptase above 20 ng/mL is highly suggestive of systemic mastocytosis. Elevated levels can also be seen after anaphylactic reactions, severe allergic episodes, and certain blood cancers. This test is valuable for patients with unexplained allergic-type symptoms, recurrent anaphylaxis, or suspected mast cell disorders.
Allergy-specific IgE testing helps identify what your immune system is reacting to so you can avoid triggers, plan immunotherapy, and reduce symptoms.
Anyone with recurrent allergy symptoms (rash, sneezing, GI distress, breathing difficulty) who wants to identify specific triggers without elimination diets or skin testing.
Sample Type
Blood draw
Fasting
Not required
Results In
3–5 business days
Performed At
Quest
Your Tryptase results will include values for each of the 1 biomarker tested, along with reference ranges. Results are reviewed by a licensed physician before being released to your secure portal.
If any values fall outside the normal range, your report will include guidance on what that may mean and recommended next steps. You'll receive an email notification when your results are ready, typically within 3–5 business days.
Typical reference range layout
Lab reports show where your value sits relative to established reference intervals—your physician interprets this in context for you.
No fasting required. For baseline testing, blood should not be drawn within 24 hours of an allergic reaction.
A Tryptase test costs $71.99 at TestWell — $77.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. Hospital outpatient labs typically bill around $300.00 self-pay for the same test, and often more. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible.
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Quest or Labcorp) | $71.99 | $77.99 | Includes the one $6 lab processing fee, charged once per order |
| Hospital outpatient lab, self-pay (typical) | $300.00 | $300.00 | Reference figure; hospital charges vary widely by facility and are often higher |
Lab test codes: Quest test code 34484 · Labcorp test no. 004280. Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
TestWell Price
$71.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
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