Also known as: Estradiol (E2), Ultrasensitive (LC/MS), Sensitive Estradiol Test, Estradiol LC/MS Test, LC-MS/MS Estradiol, Ultrasensitive E2 Test, Estradiol Sensitive (Labcorp 140244), Estradiol Ultrasensitive (Quest 30289)
On your lab requisition: Labcorp “Estradiol, Sensitive” (test no. 140244)
The short answer
Estradiol (E2), Ultrasensitive (LC/MS) measures Estradiol from a standard blood draw. At TestWell it costs $49.99 plus a $6 lab processing fee, needs no fasting, and results post in 3–6 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Quest or Labcorp.
TestWell Price
$49.99
+ $6 lab processing fee
Estradiol is the main estrogen in both sexes, but men, postmenopausal women and anyone on an aromatase inhibitor run at levels where the standard estradiol immunoassay is at its weakest: below roughly 40 pg/mL it is imprecise and cross-reacts with other steroids, so it tends to read high — a man can be told his estradiol is elevated on a number that mass spectrometry would put in range. This test measures estradiol by liquid chromatography–tandem mass spectrometry (LC-MS/MS): Quest test 30289, Estradiol, Ultrasensitive, LC/MS, or Labcorp 140244, Estradiol, Sensitive, LC/MS — the method the Endocrine Society's position statement on estradiol measurement calls for at low concentrations, and the same technique behind the CDC's reference method. It is the right estradiol test for men on testosterone therapy, where testosterone converts to estradiol and the result guides dose and aromatase-inhibitor decisions; for gynecomastia, breast tenderness or low-libido work-ups; for postmenopausal women; and for anyone whose earlier results came from a mass-spectrometry assay, because results from the two methods are not interchangeable — pick one method and stay with it when following a trend. Premenopausal women evaluating cycle or fertility hormones are well served by the standard Estradiol (E2) test at $35.99: at reproductive-years levels the immunoassay is accurate and faster. Reported in pg/mL against the lab's method-specific ranges (adult men: ≤29 pg/mL at Quest, 8–35 at Labcorp). No fasting, and the mass-spectrometry method is not affected by biotin supplements.
Sample Type
Blood draw
Fasting
Not required
Results In
3–6 business days · typical; varies by lab and draw day
Performed At
Quest or Labcorp
Your Estradiol (E2), Ultrasensitive (LC/MS) results will include values for each of the 1 biomarker tested, along with reference ranges. Results are reviewed by a licensed physician before being released to your secure portal.
If any values fall outside the normal range, your report will include guidance on what that may mean and recommended next steps. You'll receive an email notification when your results are ready, typically within 3–6 business days.
Typical reference range layout
Lab reports show where your value sits relative to established reference intervals—your physician interprets this in context for you. Already have results? Analyze them with your AI assistant against our physician-reviewed ranges.
No fasting required. On testosterone therapy, draw at the same point in your dosing cycle each time — mid-interval or just before an injection — ideally with your testosterone test. No need to pause biotin for this method.
What can throw off this result
Physician-reviewed “Before your test” pages — what each factor does, for how long, and what to do about it.
TestWell orders the same Estradiol (E2), Ultrasensitive (LC/MS) the labs run for doctors' offices, so you can walk into any of these labs with our requisition — no doctor's visit, a licensed physician authorizes the order, and most patient service centers take walk-ins. The table shows each lab's own test code, the name printed on the requisition, what the lab charges on its own consumer site, and the price through TestWell at that lab (plus one $6 fee per order).
| Lab | Test code | On the requisition | Lab's own site | Through TestWell |
|---|---|---|---|---|
| Quest Diagnostics | test code 30289 | “Estradiol (E2), Ultrasensitive (LC/MS)” | not sold direct | $49.99 + $6 |
| Labcorp | test no. 140244 | “Estradiol, Sensitive” | not sold direct | $49.99 + $6 |
| BioReference (New York & New Jersey) | test code J258-5 | “Estradiol (E2), Ultrasensitive (LC/MS)” | n/a | $54.99 + $6 |
You choose the lab at checkout; the requisition is written for that lab and arrives by email within minutes. New York and New Jersey orders draw at BioReference. Lab-direct prices are read from the labs' public pages and re-checked regularly.
Where to get it near you: patient service centers by state and city · search by ZIP code
An Estradiol (E2), Ultrasensitive (LC/MS) test costs $49.99 at TestWell — $55.99 all-in, since the $6 lab processing fee is charged once per order and there is no draw or physician fee. Hospital outpatient labs typically bill around $200.00 self-pay. With insurance you pay your plan's negotiated rate against your deductible; TestWell's price is fixed before the draw and HSA/FSA-eligible.
| Where you order | Price | One test, all-in | Notes |
|---|---|---|---|
| TestWell (drawn at Quest or Labcorp) | $49.99 | $55.99 | Includes the one $6 lab processing fee, charged once per order |
| TestWell (drawn at BioReference — New York & New Jersey) | $54.99 | $60.99 | New York and New Jersey orders route to BioReference; Quest Health and Labcorp OnDemand don't take self-ordered draws in those states |
| Hospital outpatient lab, self-pay (typical) | $200.00 | $200.00 | Reference figure; hospital charges vary widely by facility and are often higher |
Lab test codes: Quest test code 30289 · Labcorp test no. 140244 · BioReference code J258-5. Competitor prices are read from the linked public pages and re-checked regularly; the labs' sites may add taxes or change prices without notice.
Compare more: Quest Diagnostics price list · Labcorp price list · Quest vs Labcorp · Lab test price checker
Estradiol (E2), Ultrasensitive (LC/MS) test results are typically ready in 3–6 business days after your draw at Quest or Labcorp. TestWell emails you the moment they post, and your results dashboard shows each marker against its reference range with a plain-English explanation.
No, fasting is not required for an Estradiol (E2), Ultrasensitive (LC/MS) test — you can eat normally and book any time of day. On testosterone therapy, draw at the same point in your dosing cycle each time — mid-interval or just before an injection — ideally with your testosterone test. No need to pause biotin for this method.
Biotin supplements, cycle day and oral contraceptives and estrogen can change an Estradiol (E2), Ultrasensitive (LC/MS) test result without anything being wrong. Biotin supplements can shift Estradiol — stop biotin ≥72 hours; tell the lab if you can't. Cycle day can shift Estradiol — draw on cycle days 2–5 unless told otherwise. Oral contraceptives and estrogen can lower Estradiol — Cycle-day hormone testing is not meaningful on the pill or with a hormonal IUD/implant. Each is explained on our physician-reviewed "Before your test" pages; when one applies, remove it and retest.
Order the Estradiol (E2), Ultrasensitive (LC/MS) test online from TestWell for $49.99 (plus a $6 per-order lab processing fee) — no doctor's visit, referral or insurance needed. A licensed physician authorizes the order, then you walk into any Quest or Labcorp patient service center near you for the draw (the lab locator on our site lists the closest ones by ZIP code), and results arrive in 3–6 business days.
The Estradiol (E2), Ultrasensitive (LC/MS) test is Quest Diagnostics test code 30289, Labcorp test number 140244 ("Estradiol, Sensitive"), BioReference code J258-5. TestWell orders it under those codes for $49.99 at Quest, Labcorp or BioReference — no doctor's visit or insurance required, results in 3–6 business days. Codes verified against the labs' catalogs in 2026.
Medically reviewed by Youmna DiStefano, MD · Last reviewed October 2026
TestWell Price
$49.99
+ $6 lab processing fee at checkout
No insurance needed · HIPAA compliant
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