Estradiol · low result
What does a low Estradiol mean?
Short answer
Low estradiol is expected after menopause and early in the menstrual cycle, so context decides its meaning. In a woman of reproductive age with missed periods it points to ovarian insufficiency, low body weight or over-exercise, high prolactin, or a pituitary problem. In men, low estradiol on testosterone-lowering therapy or aromatase inhibitors contributes to bone loss and joint pain.
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
What is the normal range for Estradiol?
- Male, age 18+: 10.0 – 40.0 pg/mL
- Female, age 18+, varies by cycle phase: 15.0 – 350 pg/mL
Full reference table, citations and testing options: Estradiol biomarker page.
What are the common causes of low Estradiol?
- Menopause or perimenopause
- Normal early follicular phase (cycle days 2–5)
- Functional hypothalamic amenorrhea: low body weight, eating disorders, heavy exercise, stress
- Primary ovarian insufficiency, Turner syndrome
- High prolactin, pituitary disorders
- Men: aromatase inhibitors, hypogonadism
What symptoms go with low Estradiol?
- Hot flashes, night sweats, vaginal dryness
- Irregular or absent periods
- Low mood, poor sleep, joint aches
- Bone loss over time
What do clinicians usually check next?
- FSH and LH — high FSH points to the ovaries; low or normal points upstream
- Prolactin and TSH
- Pregnancy test in anyone who could be pregnant
- Bone density assessment if low estradiol is prolonged
Follow-up tests available at TestWell: TSH (Thyroid Stimulating Hormone) ($26.99), TSH + Free T4 ($27.99), FSH (Follicle Stimulating Hormone) ($29.99), Pregnancy Test (Quantitative hCG) ($26.99), LH (Luteinizing Hormone) ($36.99), Prolactin ($39.99).
How do you recheck Estradiol?
Prices are cash-pay; every order adds one $6 lab processing fee. Physician authorization is included; no insurance or referral needed.
| Test or panel | Type | Price | Fasting | Results |
|---|---|---|---|---|
| Women's Fertility Essentials | Panel · 5 tests | $119.99 | No | 3–5 business days |
| Erectile Dysfunction Panel | Panel · 7 tests | $114.99 | Yes | 2–5 business days |
| Men's Hormone Panel | Panel · 7 tests | $199.99 | No | 3–5 business days |
| Estradiol (E2) | Test | $35.99 | No | 1–3 business days |
Common questions
Does low estradiol confirm menopause?
A low estradiol with a high FSH in a woman of the right age, with 12 months without periods, fits menopause. Levels swing during perimenopause, so a single value isn't definitive.
Sources
Educational content, not a diagnosis. Lab results are one input; a clinician interprets them with your history and exam.