SHBG · high result
What does a high SHBG mean?
Short answer
High SHBG binds more testosterone and estradiol, lowering the free, active fraction — so total hormone levels can look normal while free levels are low. Common causes are oral estrogens (including birth control pills), hyperthyroidism, liver disease, aging in men, low body weight, anorexia and some anticonvulsants. Free testosterone is the number to look at when SHBG is high.
Medically reviewed by Youmna DiStefano, MD · Last reviewed September 2026
What is the normal range for SHBG?
- Male, age 18+: 16.5 – 55.9 nmol/L
- Female, age 18+: 24.6 – 122 nmol/L
Full reference table, citations and testing options: SHBG biomarker page.
What are the common causes of high SHBG?
- Oral contraceptives and oral estrogen therapy
- Hyperthyroidism
- Liver disease (cirrhosis, hepatitis)
- Aging in men, low body weight, eating disorders
- Anticonvulsants, HIV infection
- Pregnancy
What symptoms go with high SHBG?
- Low libido, fatigue if free testosterone is reduced
What do clinicians usually check next?
- Free testosterone (calculated or measured) rather than total
- TSH and liver panel
- Medication review
Follow-up tests available at TestWell: TSH (Thyroid Stimulating Hormone) ($26.99), TSH + Free T4 ($27.99).
How do you recheck SHBG?
Prices are cash-pay; every order adds one $6 lab processing fee. Physician authorization is included; no insurance or referral needed.
| Test or panel | Type | Price | Fasting | Results |
|---|---|---|---|---|
| Testosterone, Free & Total + SHBG | Test · 3 biomarkers | $69.99 | No | 3–5 business days |
Common questions
My total testosterone is normal but I have low-T symptoms. Could SHBG explain it?
Yes — high SHBG lowers free testosterone. Ask for a calculated free testosterone using the measured SHBG.
Sources
Educational content, not a diagnosis. Lab results are one input; a clinician interprets them with your history and exam.