--- title: Syphilis Test with Confirmation Test type: test id: syphilis url: "https://www.test-well.com/tests/syphilis-test" price_usd: 39.99 lab_fee_usd: 6 all_in_usd: 45.99 cpt: 86592 category: STI & Infectious Disease sample: Blood draw fasting_required: false results_in: "2–5 business days" labs: - Quest - Labcorp - BioReference orderable: true reviewed_at: 2026-09-14 order_url: "https://www.test-well.com/cart?add=syphilis-test&utm_source=ai_agent&utm_medium=markdown" --- # Syphilis Test with Confirmation Test > Syphilis Test with Confirmation measures RPR Screen and FTA-ABS Confirmation (if reactive) from a standard blood draw. At TestWell it costs $39.99 plus a $6 lab fee, needs no fasting, and results post in 2–5 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Quest or Labcorp. ## Key facts | Fact | Value | | --- | --- | | Price | $39.99 + $6 lab processing fee per order ($45.99 all-in for this test alone) | | CPT code | 86592 | | Sample | Blood draw | | Fasting | Not required | | Results | 2–5 business days | | Labs | Quest Diagnostics, Labcorp, BioReference (NY & NJ) | | Biomarkers measured | 2 | | Physician authorization | Included — no doctor's visit, referral or insurance needed | | Payment | Card, HSA or FSA; cash-pay only (no insurance billing) | ## What does the Syphilis Test with Confirmation test tell you? Screens for syphilis with automatic confirmatory testing if positive — discreet and accurate. This test uses an RPR (Rapid Plasma Reagin) screen to detect syphilis antibodies. If the screen is positive, confirmatory testing is performed automatically. Syphilis is a bacterial STI that progresses through stages and can cause serious health problems if untreated, including neurological and cardiovascular damage. Early detection enables simple, effective antibiotic treatment. **Clinical use:** Two-step screening for Treponema pallidum (the syphilis bacterium): reactive RPR/VDRL screen triggers automatic FTA-ABS confirmation. Catches active and past infections. ## Who should order it? All pregnant women (universal screening), MSM annually, anyone with new partners, anyone diagnosed with another STI, anyone with the classic painless chancre or syphilis rash. ## Biomarkers measured - RPR Screen - FTA-ABS Confirmation (if reactive) ## Price by lab | Lab | Test price | All-in (with $6 fee) | Notes | | --- | --- | --- | --- | | Quest Diagnostics | $39.99 | $45.99 | Choose at checkout; walk-in patient service centers nationwide (not NY/NJ) | | Labcorp | $39.99 | $45.99 | Choose at checkout; walk-in patient service centers nationwide (not NY/NJ) | | BioReference (NY & NJ) | $27.99 | $33.99 | New York and New Jersey orders route here automatically | Rhode Island is not served. Prices are identical online and in the lab; no draw fee or physician fee is added. ## How much does a Syphilis Test with Confirmation test cost? A Syphilis Test with Confirmation test costs $39.99 at TestWell — $45.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. Ordered directly from the labs' own consumer sites, the same test lists at $52.00 at Quest Health and $59.00 at Labcorp OnDemand (list prices checked Sep 12, 2026). Hospital outpatient labs typically bill around $150.00 self-pay for the same test, and often more. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible. | Where you order | Price | One test, all-in | Notes | | --- | --- | --- | --- | | TestWell (drawn at Quest or Labcorp) | $39.99 | $45.99 | Includes the one $6 lab processing fee, charged once per order | | Quest Health (Quest Diagnostics' own site) | $52.00 | $52.00 | [list price checked 2026-09-12](https://www.questhealth.com/product/syphilis-test-with-confirmation/36126M.html) | | Labcorp OnDemand (Labcorp's own site) | $59.00 | $59.00 | [list price checked 2026-09-12](https://www.ondemand.labcorp.com/lab-tests/syphilis-rpr-test) | | Hospital outpatient lab, self-pay (typical) | $150.00 | $150.00 | Reference figure; hospital charges vary widely by facility and are often higher | Lab test codes: Quest test code 90349 · Labcorp test no. 006072 · BioReference code J275-9. ## How do you prepare? No fasting required. Window period: 3–6 weeks after exposure. ## Related conditions - Syphilis (early) (A51.9) - Syphilis (late) (A52.9) - Congenital syphilis (A50.9) - Latent syphilis (A53.0) ## Common questions about the Syphilis Test with Confirmation test ### How is syphilis testing done? Two-step process. RPR or VDRL screens first (looks for non-specific anti-cardiolipin antibodies). If reactive, a treponemal-specific confirmatory test (FTA-ABS or TP-PA) runs automatically. This algorithm catches active infection and distinguishes it from false positives. ### How soon after exposure can syphilis be detected? Tests become reliable 3-6 weeks after exposure. Earlier testing can produce false negatives. If you've had a known exposure within the last 3 weeks and are symptomatic (painless ulcer, rash), see urgent care for clinical evaluation rather than relying on lab tests alone. ### What's a positive syphilis result? RPR titer reported as a ratio (1:1, 1:8, 1:64 — higher titers = more active infection). FTA-ABS or TP-PA reported as reactive/non-reactive. Treated syphilis often shows a positive treponemal test forever (lifelong 'serologic scar') with a negative or low RPR. ### How much does a syphilis test cost without insurance? On TestWell, the Syphilis Test with Confirmation is $39.99. Quest Direct lists the same test at $52, walk-in hospital labs typically bill $100-150 without insurance. ### What CPT codes are billed? RPR screen: CPT 86592. Treponemal confirmation (FTA-ABS): CPT 86780. Both codes appear if the screen reflexes to confirmation. ### Do I need to fast? No fasting required. Any time of day. ### Should I bundle this with a full STI panel? Yes if you haven't been tested recently. The [STI Comprehensive Panel](https://www.test-well.com/tests/sti-comprehensive-panel) includes syphilis plus [HIV](https://www.test-well.com/tests/hiv-test), [chlamydia & gonorrhea](https://www.test-well.com/tests/chlamydia-gonorrhea), [hepatitis B](https://www.test-well.com/tests/hepatitis-b-test), and [hepatitis C](https://www.test-well.com/tests/hepatitis-c-test) at a discount. ## How to order 1. Add to cart: https://www.test-well.com/cart?add=syphilis-test&utm_source=ai_agent&utm_medium=markdown 2. Create an account or sign in, confirm your state and preferred lab, pay by card, HSA or FSA. 3. A licensed physician authorizes the order (usually within minutes); the requisition arrives by email. 4. Walk into any Quest Diagnostics, Labcorp, BioReference (NY & NJ) patient service center — no appointment needed at most sites. 5. Results post to your TestWell portal in 2–5 business days with reference ranges and flags. ## Related - [Immigration Exam Prep Panel](https://www.test-well.com/tests/immigration-exam-prep-panel) — 3 tests · $159.99 - [STI Comprehensive Panel](https://www.test-well.com/tests/sti-comprehensive-panel) — 7 tests · $249.99 - [Early Pregnancy Panel](https://www.test-well.com/tests/prenatal-screening-panel) — 9 tests · $249.99 - [CMV IgG + IgM Antibodies (Cytomegalovirus)](https://www.test-well.com/tests/cmv-igg-igm-antibodies) — $74.99 - [CMV IgG Antibody (Cytomegalovirus)](https://www.test-well.com/tests/cmv-igg-antibody) — $40.99 - [CMV IgM Antibody (Cytomegalovirus)](https://www.test-well.com/tests/cmv-igm-antibody) — $40.99 - [Hepatitis B Test with Confirmation](https://www.test-well.com/tests/hepatitis-b-test) — $59.99 - [Hepatitis C Test with Confirmation](https://www.test-well.com/tests/hepatitis-c-test) — $30.99 - [All STI & Infectious Disease tests](https://www.test-well.com/tests/category/sti-infectious-disease) - [Full test directory](https://www.test-well.com/tests/directory) --- Medically reviewed by Youmna DiStefano, MD (Medical Reviewer, TestWell); last reviewed 2026-09-14. Review policy: https://www.test-well.com/reviewers/youmna-distefano-md Canonical page: https://www.test-well.com/tests/syphilis-test Machine-readable catalog: https://www.test-well.com/api/catalog.json · MCP server: https://www.test-well.com/mcp · Overview for agents: https://www.test-well.com/llms.txt Prices are cash-pay, in USD, and include physician authorization; every order adds one flat $6 lab processing fee. Educational content is not a diagnosis — discuss results with a clinician.