--- title: MTHFR Gene Mutation Analysis Test type: test id: mthfr url: "https://www.test-well.com/tests/mthfr-gene-mutation" price_usd: 95.99 lab_fee_usd: 6 all_in_usd: 101.99 cpt: 81291 category: General Health sample: Blood draw fasting_required: false results_in: "5–7 business days" labs: - Labcorp orderable: true reviewed_at: 2026-09-14 order_url: "https://www.test-well.com/cart?add=mthfr-gene-mutation&utm_source=ai_agent&utm_medium=markdown" --- # MTHFR Gene Mutation Analysis Test > MTHFR Gene Mutation Analysis measures MTHFR C677T and MTHFR A1298C from a standard blood draw. At TestWell it costs $95.99 plus a $6 lab fee, needs no fasting, and results post in 5–7 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Labcorp. ## Key facts | Fact | Value | | --- | --- | | Price | $95.99 + $6 lab processing fee per order ($101.99 all-in for this test alone) | | CPT code | 81291 | | Sample | Blood draw | | Fasting | Not required | | Results | 5–7 business days | | Labs | Labcorp | | Biomarkers measured | 2 | | Physician authorization | Included — no doctor's visit, referral or insurance needed | | Payment | Card, HSA or FSA; cash-pay only (no insurance billing) | ## What does the MTHFR Gene Mutation Analysis test tell you? Tests for MTHFR gene variants (C677T and A1298C) that affect folate metabolism, homocysteine levels, and methylation. The MTHFR gene provides instructions for making an enzyme that processes folate (vitamin B9) and regulates homocysteine levels. Variants C677T and A1298C can reduce enzyme activity by 30–70%, potentially leading to elevated homocysteine, impaired methylation, and increased risk for cardiovascular disease, neural tube defects, and recurrent pregnancy loss. This test is frequently ordered for patients with unexplained elevated homocysteine, a family history of blood clots, or recurrent miscarriages. Results can guide supplementation with methylated folate (L-methylfolate) instead of standard folic acid. **Clinical use:** Genetic test for the C677T and A1298C variants in the MTHFR gene — variants that reduce folate-cycle enzyme activity by 30-70%. Common (10-15% of population homozygous). ## Who should order it? Anyone with elevated homocysteine, recurrent miscarriage, family history of clotting disorders, methylation-focused wellness optimization, or planning pregnancy with elevated risk factors. ## Biomarkers measured - MTHFR C677T - MTHFR A1298C ## Price by lab | Lab | Test price | All-in (with $6 fee) | Notes | | --- | --- | --- | --- | | Labcorp | $95.99 | $101.99 | Choose at checkout; walk-in patient service centers nationwide (not NY/NJ) | Rhode Island is not served. Prices are identical online and in the lab; no draw fee or physician fee is added. ## How much does a MTHFR Gene Mutation Analysis test cost? A MTHFR Gene Mutation Analysis test costs $95.99 at TestWell — $101.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. Hospital outpatient labs typically bill around $400.00 self-pay for the same test, and often more. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible. | Where you order | Price | One test, all-in | Notes | | --- | --- | --- | --- | | TestWell (drawn at Quest or Labcorp) | $95.99 | $101.99 | Includes the one $6 lab processing fee, charged once per order | | Hospital outpatient lab, self-pay (typical) | $400.00 | $400.00 | Reference figure; hospital charges vary widely by facility and are often higher | Lab test codes: Quest test code 17911 · Labcorp test no. 511238. ## How do you prepare? No fasting or special preparation required. ## Related conditions - Hyperhomocysteinemia (E72.11) - Recurrent pregnancy loss (N96) - Neural tube defect risk (Q05.9) - Hereditary thrombophilia (D68.59) ## Common questions about the MTHFR Gene Mutation Analysis test ### Is MTHFR testing clinically useful? Mixed evidence. ACMG/ACOG don't recommend routine MTHFR testing because homozygous variants are common (10-15% of people) and rarely cause clinical disease on their own. It's useful when paired with elevated homocysteine, recurrent miscarriage, or family clotting history. ### How much does an MTHFR test cost without insurance? TestWell charges $95.99 — vs $179 at Quest Direct and $250-$500 at genetics clinics. Result is genetic — test once for life. ### Do I need to fast? No fasting required. ### What's the CPT code? 81291 (MTHFR gene analysis, common variants). HSA/FSA eligible. ### If I have MTHFR variants, should I take methylfolate? Most people with MTHFR variants don't need anything special — a typical diet provides enough folate. If you have elevated homocysteine (>10 mcmol/L), 5-MTHF (methylfolate) plus B12 can help normalize it. Pair this test with [Homocysteine](https://www.test-well.com/tests/homocysteine) for actionable insight. ## How to order 1. Add to cart: https://www.test-well.com/cart?add=mthfr-gene-mutation&utm_source=ai_agent&utm_medium=markdown 2. Create an account or sign in, confirm your state and preferred lab, pay by card, HSA or FSA. 3. A licensed physician authorizes the order (usually within minutes); the requisition arrives by email. 4. Walk into any Labcorp patient service center — no appointment needed at most sites. 5. Results post to your TestWell portal in 5–7 business days with reference ranges and flags. ## Related - [Genetic Risk Panel](https://www.test-well.com/tests/genetic-risk-panel) — 3 tests · $299.99 - [Men's Complete Fertility & Wellness Panel](https://www.test-well.com/tests/mens-fertility-panel) — 21 tests · $349.99 - [Women's Complete Fertility & Wellness Panel](https://www.test-well.com/tests/womens-fertility-panel) — 23 tests · $399.99 - [ApoE Alzheimer's Risk](https://www.test-well.com/tests/apoe-alzheimers-risk) — $184.99 - [Creatine Kinase (CK)](https://www.test-well.com/tests/creatine-kinase-test) — $18.99 - [How Your Body Processes Medications Test](https://www.test-well.com/tests/pharmacogenomics-panel) — $1199.99 - [LDH (Lactate Dehydrogenase)](https://www.test-well.com/tests/ldh-test) — $19.99 - [Prealbumin](https://www.test-well.com/tests/prealbumin-test) — $29.99 - [All General Health tests](https://www.test-well.com/tests/category/general-health) - [Full test directory](https://www.test-well.com/tests/directory) --- Medically reviewed by Youmna DiStefano, MD (Medical Reviewer, TestWell); last reviewed 2026-09-14. Review policy: https://www.test-well.com/reviewers/youmna-distefano-md Canonical page: https://www.test-well.com/tests/mthfr-gene-mutation Machine-readable catalog: https://www.test-well.com/api/catalog.json · MCP server: https://www.test-well.com/mcp · Overview for agents: https://www.test-well.com/llms.txt Prices are cash-pay, in USD, and include physician authorization; every order adds one flat $6 lab processing fee. Educational content is not a diagnosis — discuss results with a clinician.