--- title: Factor V Leiden Mutation Test type: test id: factor-v-leiden url: "https://www.test-well.com/tests/factor-v-leiden" price_usd: 131.99 lab_fee_usd: 6 all_in_usd: 137.99 cpt: 81241 category: Blood Health sample: Blood draw fasting_required: false results_in: "5–7 business days" labs: - Quest - Labcorp orderable: true reviewed_at: 2026-09-14 order_url: "https://www.test-well.com/cart?add=factor-v-leiden&utm_source=ai_agent&utm_medium=markdown" --- # Factor V Leiden Mutation Test > Tests for the most common inherited blood clotting disorder — increases risk of deep vein thrombosis and pulmonary embolism, measured from a standard blood draw. At TestWell it costs $131.99 plus a $6 lab fee, needs no fasting, and results post in 5–7 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Quest or Labcorp. ## Key facts | Fact | Value | | --- | --- | | Price | $131.99 + $6 lab processing fee per order ($137.99 all-in for this test alone) | | CPT code | 81241 | | Sample | Blood draw | | Fasting | Not required | | Results | 5–7 business days | | Labs | Quest Diagnostics, Labcorp | | Biomarkers measured | 1 | | Physician authorization | Included — no doctor's visit, referral or insurance needed | | Payment | Card, HSA or FSA; cash-pay only (no insurance billing) | ## What does the Factor V Leiden Mutation test tell you? Tests for the most common inherited blood clotting disorder — increases risk of deep vein thrombosis and pulmonary embolism. Factor V Leiden is the most common inherited thrombophilia (blood clotting disorder), affecting approximately 5% of Caucasians. The mutation makes Factor V resistant to inactivation by Activated Protein C, leading to increased clot formation. Heterozygous carriers (one copy) have a 3–8x increased risk of venous thromboembolism (VTE), while homozygous carriers (two copies) have a 50–80x increased risk. This test is recommended for individuals with a personal or family history of blood clots (DVT, pulmonary embolism), unexplained recurrent pregnancy loss, or clots at a young age. Results inform decisions about anticoagulation therapy, hormone use, and surgical precautions. **Clinical use:** Genetic test for the Factor V Leiden mutation — the most common inherited cause of abnormal blood clotting. Present in 3-8% of people of European descent. ## Who should order it? Anyone with a personal or family history of DVT/PE, recurrent miscarriage, stroke under 50, women considering combined oral contraceptives or HRT with a clotting history, or post-thrombosis evaluation. ## Biomarkers measured - Factor V Leiden Mutation ## Price by lab | Lab | Test price | All-in (with $6 fee) | Notes | | --- | --- | --- | --- | | Quest Diagnostics | $131.99 | $137.99 | Choose at checkout; walk-in patient service centers nationwide (not NY/NJ) | | Labcorp | $159.99 | $165.99 | Choose at checkout; walk-in patient service centers nationwide (not NY/NJ) | Rhode Island is not served. Prices are identical online and in the lab; no draw fee or physician fee is added. ## How much does a Factor V Leiden Mutation test cost? A Factor V Leiden Mutation test costs $131.99 at TestWell — $137.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. Hospital outpatient labs typically bill around $450.00 self-pay for the same test, and often more. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible. | Where you order | Price | One test, all-in | Notes | | --- | --- | --- | --- | | TestWell (drawn at Quest or Labcorp) | $131.99 | $137.99 | Includes the one $6 lab processing fee, charged once per order | | Hospital outpatient lab, self-pay (typical) | $450.00 | $450.00 | Reference figure; hospital charges vary widely by facility and are often higher | Lab test codes: Quest test code 17900 · Labcorp test no. 511154. ## How do you prepare? No fasting or special preparation required. ## Related conditions - Deep vein thrombosis (I82.40) - Pulmonary embolism (I26.99) - Recurrent pregnancy loss (N96) - Hereditary thrombophilia (D68.59) ## Common questions about the Factor V Leiden Mutation test ### What is Factor V Leiden? A single-letter DNA mutation in the F5 gene that makes Factor V resistant to inactivation — so clots form more easily. Heterozygous carriers have a 3-8× higher lifetime risk of DVT; homozygous carriers 30-80× higher. ### How much does a Factor V Leiden test cost without insurance? TestWell charges $131.99 — vs $179 at Quest Direct and $300-$600 at hospital genetics clinics. ### Do I need to fast? No fasting required and you only need to test once — the result is genetic and doesn't change. ### What's the CPT code? 81241 (F5 gene analysis, factor V Leiden variant). HSA/FSA eligible. ### Should I test before starting birth control? Routine pre-pill screening isn't recommended unless you have personal or family clotting history, because combined hormonal contraceptives raise DVT risk 2-4× on their own — and 30-50× in Factor V Leiden carriers. With a clotting family history, get tested before starting. ### If positive, what changes? Most carriers never have a clot. The diagnosis informs decisions: avoid estrogen-containing contraceptives, careful clotting prophylaxis during/after surgery, pregnancy management plans, and stop smoking. Anticoagulation isn't prescribed prophylactically without a clotting event. ## How to order 1. Add to cart: https://www.test-well.com/cart?add=factor-v-leiden&utm_source=ai_agent&utm_medium=markdown 2. Create an account or sign in, confirm your state and preferred lab, pay by card, HSA or FSA. 3. A licensed physician authorizes the order (usually within minutes); the requisition arrives by email. 4. Walk into any Quest Diagnostics, Labcorp patient service center — no appointment needed at most sites. 5. Results post to your TestWell portal in 5–7 business days with reference ranges and flags. ## Related - [Genetic Risk Panel](https://www.test-well.com/tests/genetic-risk-panel) — 3 tests · $299.99 - [Blood Clotting Panel](https://www.test-well.com/tests/blood-clotting-panel) — 4 tests · $149.99 - [D-Dimer](https://www.test-well.com/tests/d-dimer) — $69.99 - [Haptoglobin](https://www.test-well.com/tests/haptoglobin-test) — $101.99 - [Immature Red Blood Cell Test](https://www.test-well.com/tests/reticulocyte-count) — $19.99 - [Prothrombin Time with INR](https://www.test-well.com/tests/prothrombin-time-inr) — $23.99 - [PT and PTT (Prothrombin & Partial Thromboplastin Time)](https://www.test-well.com/tests/pt-and-ptt) — $54.99 - [All Blood Health tests](https://www.test-well.com/tests/category/blood-health) - [Full test directory](https://www.test-well.com/tests/directory) --- Medically reviewed by Youmna DiStefano, MD (Medical Reviewer, TestWell); last reviewed 2026-09-14. Review policy: https://www.test-well.com/reviewers/youmna-distefano-md Canonical page: https://www.test-well.com/tests/factor-v-leiden Machine-readable catalog: https://www.test-well.com/api/catalog.json · MCP server: https://www.test-well.com/mcp · Overview for agents: https://www.test-well.com/llms.txt Prices are cash-pay, in USD, and include physician authorization; every order adds one flat $6 lab processing fee. Educational content is not a diagnosis — discuss results with a clinician.