--- title: Estradiol (E2), Ultrasensitive (LC/MS) Test type: test id: estradiol-ultrasensitive url: "https://www.test-well.com/tests/estradiol-ultrasensitive" price_usd: 49.99 lab_fee_usd: 6 all_in_usd: 55.99 category: Hormones sample: Blood draw fasting_required: false results_in: "3–6 business days" labs: - Quest - Labcorp - BioReference orderable: true reviewed_at: 2026-10-18 order_url: "https://www.test-well.com/cart?add=estradiol-ultrasensitive&utm_source=ai_agent&utm_medium=markdown" --- # Estradiol (E2), Ultrasensitive (LC/MS) Test > Estradiol (E2), Ultrasensitive (LC/MS) measures Estradiol from a standard blood draw. At TestWell it costs $49.99 plus a $6 lab processing fee, needs no fasting, and results post in 3–6 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Quest or Labcorp. **Also known as:** Sensitive Estradiol Test, Estradiol LC/MS Test, LC-MS/MS Estradiol, Ultrasensitive E2 Test, Estradiol Sensitive (Labcorp 140244), Estradiol Ultrasensitive (Quest 30289) **On your lab requisition:** Labcorp "Estradiol, Sensitive" (test no. 140244) ## Key facts | Fact | Value | | --- | --- | | Price | $49.99 + $6 lab processing fee per order ($55.99 all-in for this test alone) | | Sample | Blood draw | | Fasting | Not required | | Results | 3–6 business days | | Labs | Quest Diagnostics, Labcorp, BioReference (NY & NJ) | | Biomarkers measured | 1 | | Physician authorization | Included — no doctor's visit, referral or insurance needed | | Payment | Card, HSA or FSA; cash-pay only (no insurance billing) | ## What does the Estradiol (E2), Ultrasensitive (LC/MS) test tell you? Estradiol measured by LC-MS/MS — the method that reads accurately at the low levels seen in men, on testosterone therapy and after menopause, where the standard estradiol immunoassay tends to read high. The estradiol test to pair with a mass-spectrometry testosterone. Estradiol is the main estrogen in both sexes, but men, postmenopausal women and anyone on an aromatase inhibitor run at levels where the standard estradiol immunoassay is at its weakest: below roughly 40 pg/mL it is imprecise and cross-reacts with other steroids, so it tends to read high — a man can be told his estradiol is elevated on a number that mass spectrometry would put in range. This test measures estradiol by liquid chromatography–tandem mass spectrometry (LC-MS/MS): Quest test 30289, Estradiol, Ultrasensitive, LC/MS, or Labcorp 140244, Estradiol, Sensitive, LC/MS — the method the Endocrine Society's position statement on estradiol measurement calls for at low concentrations, and the same technique behind the CDC's reference method. It is the right estradiol test for men on testosterone therapy, where testosterone converts to estradiol and the result guides dose and aromatase-inhibitor decisions; for gynecomastia, breast tenderness or low-libido work-ups; for postmenopausal women; and for anyone whose earlier results came from a mass-spectrometry assay, because results from the two methods are not interchangeable — pick one method and stay with it when following a trend. Premenopausal women evaluating cycle or fertility hormones are well served by the standard Estradiol (E2) test at $35.99: at reproductive-years levels the immunoassay is accurate and faster. Reported in pg/mL against the lab's method-specific ranges (adult men: ≤29 pg/mL at Quest, 8–35 at Labcorp). No fasting, and the mass-spectrometry method is not affected by biotin supplements. ## Biomarkers measured - [Estradiol](https://www.test-well.com/biomarkers/estradiol) ## Price by lab | Lab | Test price | All-in (with $6 fee) | Notes | | --- | --- | --- | --- | | Quest Diagnostics | $49.99 | $55.99 | Choose at checkout; walk-in patient service centers nationwide (not NY/NJ) | | Labcorp | $49.99 | $55.99 | Choose at checkout; walk-in patient service centers nationwide (not NY/NJ) | | BioReference (NY & NJ) | $54.99 | $60.99 | New York and New Jersey orders route here automatically | Rhode Island is not served. Prices are identical online and in the lab; no draw fee or physician fee is added. ## How much does an Estradiol (E2), Ultrasensitive (LC/MS) test cost? An Estradiol (E2), Ultrasensitive (LC/MS) test costs $49.99 at TestWell — $55.99 all-in, since the $6 lab processing fee is charged once per order and there is no draw or physician fee. Hospital outpatient labs typically bill around $200.00 self-pay. With insurance you pay your plan's negotiated rate against your deductible; TestWell's price is fixed before the draw and HSA/FSA-eligible. | Where you order | Price | One test, all-in | Notes | | --- | --- | --- | --- | | TestWell (drawn at Quest or Labcorp) | $49.99 | $55.99 | Includes the one $6 lab processing fee, charged once per order | | TestWell (drawn at BioReference — New York & New Jersey) | $54.99 | $60.99 | New York and New Jersey orders route to BioReference; Quest Health and Labcorp OnDemand don't take self-ordered draws in those states | | Hospital outpatient lab, self-pay (typical) | $200.00 | $200.00 | Reference figure; hospital charges vary widely by facility and are often higher | Lab test codes: Quest test code 30289 · Labcorp test no. 140244 · BioReference code J258-5. ## How do you prepare? No fasting required. On testosterone therapy, draw at the same point in your dosing cycle each time — mid-interval or just before an injection — ideally with your testosterone test. No need to pause biotin for this method. ## Common questions about the Estradiol (E2), Ultrasensitive (LC/MS) test ### How long does it take to get Estradiol (E2), Ultrasensitive (LC/MS) test results? Estradiol (E2), Ultrasensitive (LC/MS) test results are typically ready in 3–6 business days after your draw at Quest or Labcorp. TestWell emails you the moment they post, and your results dashboard shows each marker against its reference range with a plain-English explanation. ### Do I need to fast, or can I eat before an Estradiol (E2), Ultrasensitive (LC/MS) test? No, fasting is not required for an Estradiol (E2), Ultrasensitive (LC/MS) test — you can eat normally and book any time of day. On testosterone therapy, draw at the same point in your dosing cycle each time — mid-interval or just before an injection — ideally with your testosterone test. No need to pause biotin for this method. ### What can throw off an Estradiol (E2), Ultrasensitive (LC/MS) test result? Biotin supplements, cycle day and oral contraceptives and estrogen can change an Estradiol (E2), Ultrasensitive (LC/MS) test result without anything being wrong. Biotin supplements can shift Estradiol — stop biotin ≥72 hours; tell the lab if you can't. Cycle day can shift Estradiol — draw on cycle days 2–5 unless told otherwise. Oral contraceptives and estrogen can lower Estradiol — Cycle-day hormone testing is not meaningful on the pill or with a hormonal IUD/implant. Each is explained on our physician-reviewed "Before your test" pages; when one applies, remove it and retest. ### Where can I get an Estradiol (E2), Ultrasensitive (LC/MS) test near me without a doctor? Order the Estradiol (E2), Ultrasensitive (LC/MS) test online from TestWell for $49.99 (plus a $6 per-order lab processing fee) — no doctor's visit, referral or insurance needed. A licensed physician authorizes the order, then you walk into any Quest or Labcorp patient service center near you for the draw (the lab locator on our site lists the closest ones by ZIP code), and results arrive in 3–6 business days. ### What are the Quest, Labcorp and BioReference test codes for an Estradiol (E2), Ultrasensitive (LC/MS) test? The Estradiol (E2), Ultrasensitive (LC/MS) test is Quest Diagnostics test code 30289, Labcorp test number 140244 ("Estradiol, Sensitive"), BioReference code J258-5. TestWell orders it under those codes for $49.99 at Quest, Labcorp or BioReference — no doctor's visit or insurance required, results in 3–6 business days. Codes verified against the labs' catalogs in 2026. ## How to order 1. Add to cart: https://www.test-well.com/cart?add=estradiol-ultrasensitive&utm_source=ai_agent&utm_medium=markdown 2. Create an account or sign in, confirm your state and preferred lab, pay by card, HSA or FSA. 3. A licensed physician authorizes the order (usually within minutes); the requisition arrives by email. 4. Walk into any Quest Diagnostics, Labcorp, BioReference (NY & NJ) patient service center — no appointment needed at most sites. 5. Results post to your TestWell portal in 3–6 business days with reference ranges and flags. ## Related - [Adiponectin](https://www.test-well.com/tests/adiponectin) — $36.99 - [Aldosterone](https://www.test-well.com/tests/aldosterone-test) — $61.99 - [Antidiuretic Hormone (ADH) Profile](https://www.test-well.com/tests/antidiuretic-hormone-profile) — $109.99 - [Cortisol (AM)](https://www.test-well.com/tests/cortisol-am) — $26.99 - [Cortisol, PM](https://www.test-well.com/tests/cortisol-pm) — $34.99 - [All Hormones tests](https://www.test-well.com/tests/category/hormones) - [Full test directory](https://www.test-well.com/tests/directory) --- Medically reviewed by Youmna DiStefano, MD (Medical Reviewer, TestWell); last reviewed 2026-10-18. Review policy: https://www.test-well.com/reviewers/youmna-distefano-md Canonical page: https://www.test-well.com/tests/estradiol-ultrasensitive Machine-readable catalog: https://www.test-well.com/api/catalog.json · MCP server: https://www.test-well.com/mcp · Overview for agents: https://www.test-well.com/llms.txt Prices are cash-pay, in USD, and include physician authorization; every order adds one flat $6 lab processing fee. Educational content is not a diagnosis — discuss results with a clinician.