--- title: Comprehensive B12 Deficiency Panel type: panel id: b12-deficiency-panel url: "https://www.test-well.com/tests/b12-deficiency-panel" price_usd: 79.99 lab_fee_usd: 6 all_in_usd: 85.99 tests_included: 3 biomarkers_measured: 3 category: Vitamins & Nutrients sample: Blood draw fasting_required: true results_in: "5–12 business days" labs: - Quest - Labcorp - BioReference orderable: true reviewed_at: 2026-09-14 order_url: "https://www.test-well.com/cart?add=b12-deficiency-panel&utm_source=ai_agent&utm_medium=markdown" --- # Comprehensive B12 Deficiency Panel > Comprehensive B12 Deficiency Panel bundles 3 tests — Vitamin B12, Methylmalonic Acid (MMA) and Homocysteine — for $79.99 all-in (about $26.66 per test). Fast 8–12 hours before the draw; results post in 5–12 business days. Physician-authorized with no doctor's visit or insurance needed; one draw at Quest or Labcorp. *Not just your B12 level — whether your cells can use it* ## Key facts | Fact | Value | | --- | --- | | Price | $79.99 + $6 lab processing fee per order ($85.99 all-in) | | Versus buying separately | $103.97 for the 3 tests individually — the panel saves 23% | | Tests included | 3 | | Biomarkers measured | 3 | | Sample | Blood draw | | Fasting | Yes — 8–12 hours | | Results | 5–12 business days | | Labs | Quest Diagnostics, Labcorp, BioReference (NY & NJ) | | Physician authorization | Included — no doctor's visit, referral or insurance needed | ## What does the Comprehensive B12 Deficiency Panel cover? The complete B12 workup — serum B12 plus methylmalonic acid (MMA) and homocysteine, the two functional markers that confirm a true deficiency. A serum B12 test alone misses early and borderline deficiency — levels can look 'normal' while your cells are already running short. This panel adds the two functional markers clinicians use to settle the question: methylmalonic acid (MMA), which accumulates early and specifically when usable B12 is low, and homocysteine, which rises with both B12 and folate deficiency. Read together, the pattern is diagnostic: elevated MMA with elevated homocysteine points to true B12 deficiency, while elevated homocysteine with normal MMA points to folate instead. It's the right panel when B12 came back borderline, when deficiency symptoms (fatigue, numbness and tingling, brain fog, memory changes) persist despite a normal B12, or when you're verifying that supplementation is actually working. Note: MMA is a specialty assay, so results take longer than routine bloodwork. **Clinical use:** Vitamin and nutrient testing identifies deficiencies that can drive fatigue, immune dysfunction, neurological symptoms, and long-term disease risk — and confirms that supplementation is working. ## Who should order it? Anyone with restrictive diets (vegan, low-fat, low-carb), malabsorption conditions, fatigue, hair loss, mood changes, or currently supplementing and wanting to verify dosing. ## Tests included | Test | Biomarkers | Standalone price | CPT | | --- | --- | --- | --- | | [Vitamin B12](https://www.test-well.com/tests/vitamin-b12) | 1 (Vitamin B12) | $25.99 | 82607 | | [Methylmalonic Acid (MMA)](https://www.test-well.com/tests/methylmalonic-acid) | 1 (Methylmalonic Acid) | $49.99 | 83921 | | [Homocysteine](https://www.test-well.com/tests/homocysteine) | 1 (Homocysteine) | $27.99 | 83090 | ## Price by lab | Lab | Panel price | All-in (with $6 fee) | Notes | | --- | --- | --- | --- | | Quest Diagnostics | $79.99 | $85.99 | Choose at checkout | | Labcorp | $79.99 | $85.99 | Choose at checkout | | BioReference (NY & NJ) | $84.99 | $90.99 | New York and New Jersey orders route here automatically | ## How much does a Comprehensive B12 Deficiency Panel cost? A Comprehensive B12 Deficiency Panel costs $79.99 at TestWell — $85.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible. | Where you order | Price | One test, all-in | Notes | | --- | --- | --- | --- | | TestWell (drawn at Quest or Labcorp) | $79.99 | $85.99 | Includes the one $6 lab processing fee, charged once per order | ## How do you prepare? Fasting for 8–12 hours recommended (homocysteine reads most accurately fasted). Water is okay. MMA is a specialty send-out assay — allow extra time for results. ## Related conditions - Vitamin deficiency (E56.9) - Nutrient deficiency (E63.9) ## Common questions about the Comprehensive B12 Deficiency Panel ### What tests are included in the Comprehensive B12 Deficiency Panel? The Comprehensive B12 Deficiency Panel includes 3 individual lab tests, bundled at a single panel price below the cost of ordering each test separately. See the full biomarker list and clinical context on the panel page. ### How long do Comprehensive B12 Deficiency Panel results take? Most Comprehensive B12 Deficiency Panel results are available in 5–12 business days after your specimen arrives at the lab. You'll get an email the moment results are ready, with everything viewable in your TestWell portal. ### What sample is collected for the Comprehensive B12 Deficiency Panel? Blood draw. Sample is collected at a Quest, Labcorp, or BioReference patient service center near you, or via at-home phlebotomy where available. ### How much does the Comprehensive B12 Deficiency Panel cost without insurance? On TestWell, the Comprehensive B12 Deficiency Panel is $79.99. Quest Direct lists comparable bundles at $193. Insurance is not required — pay one all-in price. ### Do I need to fast before the Comprehensive B12 Deficiency Panel? Yes — fasting for 8–12 hours recommended (homocysteine reads most accurately fasted). Water is okay. MMA is a specialty send-out assay — allow extra time for results. Following the prep instructions gives you the most accurate result. ### Where can I get the Comprehensive B12 Deficiency Panel done? Order online at TestWell — we'll generate a digital requisition and route you to the closest in-network lab. 4,000+ Quest, Labcorp, and BioReference patient service centers nationwide. ## How to order 1. Add to cart: https://www.test-well.com/cart?add=b12-deficiency-panel&utm_source=ai_agent&utm_medium=markdown 2. Create an account or sign in, confirm your state and preferred lab, pay by card, HSA or FSA. 3. A licensed physician authorizes the order (usually within minutes); the requisition arrives by email. 4. One draw at any Quest Diagnostics, Labcorp, BioReference (NY & NJ) patient service center covers every test in the panel. 5. Results post to your TestWell portal in 5–12 business days. ## Related - [Methylmalonic Acid (MMA) and B12 Deficiency: Why the Test Is Ordered and How to Read It](https://www.test-well.com/guides/methylmalonic-acid-b12-deficiency) - [Basic Vitamin Deficiency Panel](https://www.test-well.com/tests/vitamin-deficiency-panel) — 3 tests · $89.99 - [Vitamin & Mineral Deficiency Panel](https://www.test-well.com/tests/vitamin-mineral-panel) — 9 tests · $189.99 - [All Vitamins & Nutrients tests](https://www.test-well.com/tests/category/vitamins-nutrients) - [Full test directory](https://www.test-well.com/tests/directory) --- Medically reviewed by Youmna DiStefano, MD (Medical Reviewer, TestWell); last reviewed 2026-09-14. Review policy: https://www.test-well.com/reviewers/youmna-distefano-md Canonical page: https://www.test-well.com/tests/b12-deficiency-panel Machine-readable catalog: https://www.test-well.com/api/catalog.json · MCP server: https://www.test-well.com/mcp · Overview for agents: https://www.test-well.com/llms.txt Prices are cash-pay, in USD, and include physician authorization; every order adds one flat $6 lab processing fee. Educational content is not a diagnosis — discuss results with a clinician.