--- title: Autoimmune Advanced Panel type: panel id: autoimmune-advanced url: "https://www.test-well.com/tests/autoimmune-advanced-panel" price_usd: 159.99 lab_fee_usd: 6 all_in_usd: 165.99 tests_included: 11 biomarkers_measured: 39 category: Inflammation & Autoimmune sample: Blood draw fasting_required: false results_in: "3–5 business days" labs: - Quest - Labcorp orderable: true reviewed_at: 2026-09-14 order_url: "https://www.test-well.com/cart?add=autoimmune-advanced-panel&utm_source=ai_agent&utm_medium=markdown" --- # Autoimmune Advanced Panel > Autoimmune Advanced Panel bundles 11 tests — Autoimmune Antibody Screen (ANA), Sed Rate (ESR) and Heart & Body Inflammation Test (hs-CRP) plus 8 more — for $159.99 all-in (about $14.54 per test). No fasting is needed; results post in 3–5 business days. Physician-authorized with no doctor's visit or insurance needed; one draw at Quest or Labcorp. *ANA, thyroid antibodies, inflammation markers, and rheumatoid screening* ## Key facts | Fact | Value | | --- | --- | | Price | $159.99 + $6 lab processing fee per order ($165.99 all-in) | | Versus buying separately | $312.89 for the 11 tests individually — the panel saves 49% | | Tests included | 11 | | Biomarkers measured | 39 | | Sample | Blood draw | | Fasting | Not required | | Results | 3–5 business days | | Labs | Quest Diagnostics, Labcorp | | Physician authorization | Included — no doctor's visit, referral or insurance needed | ## What does the Autoimmune Advanced Panel cover? 11 tests for comprehensive autoimmune screening. Includes ANA with reflex, ESR, hs-CRP, TPO and thyroglobulin antibodies, ferritin, vitamin D, rheumatoid factor, CCP antibodies, CBC, and CMP. The Autoimmune Advanced Panel screens for the most common autoimmune conditions including lupus (ANA screen with reflex), rheumatoid arthritis (rheumatoid factor, anti-CCP antibodies), Hashimoto's thyroiditis (TPO and thyroglobulin antibodies), and general autoimmune inflammation (ESR, hs-CRP). Ferritin and vitamin D are included because deficiencies in both are strongly associated with autoimmune flares and disease activity. CBC and CMP provide essential baseline context for interpreting autoimmune markers. This panel is ideal for anyone with suspected autoimmune symptoms (joint pain, fatigue, rashes, hair loss) or a family history of autoimmune disease. **Clinical use:** Advanced autoimmune workup beyond the basic panel: ANA Screen, anti-dsDNA, anti-Smith, ANCA (P-ANCA + C-ANCA), Rheumatoid Factor, anti-CCP, complement C3/C4, ESR, hs-CRP. Disease-specific diagnosis when basic autoimmune panel is positive. ## Who should order it? Anyone with positive ANA on a basic autoimmune workup, suspected systemic lupus (joint pain + rash + fatigue), suspected vasculitis (skin + kidney + lung symptoms), confirming and subtyping connective tissue disease. ## Tests included | Test | Biomarkers | Standalone price | CPT | | --- | --- | --- | --- | | [Autoimmune Antibody Screen (ANA)](https://www.test-well.com/tests/ana-screen) | 3 (ANA Screen, Titer (if positive), Pattern (if positive)) | $32.99 | 86038 | | [Sed Rate (ESR)](https://www.test-well.com/tests/sed-rate-esr) | 1 (ESR (Erythrocyte Sedimentation Rate)) | $24.99 | 85652 | | [Heart & Body Inflammation Test (hs-CRP)](https://www.test-well.com/tests/hs-crp) | 1 (hs-CRP) | $34.99 | 86141 | | [Thyroid Peroxidase (TPO) Antibodies](https://www.test-well.com/tests/tpo-antibodies) | 1 (TPO Antibodies) | $25.99 | 86376 | | [Thyroglobulin Antibodies](https://www.test-well.com/tests/thyroglobulin-antibodies) | 1 (Thyroglobulin Antibodies) | $26.99 | 86800 | | [Ferritin](https://www.test-well.com/tests/ferritin) | 1 (Ferritin) | $24.99 | 82728 | | [Vitamin D, 25-Hydroxy](https://www.test-well.com/tests/vitamin-d) | 1 (25-Hydroxy Vitamin D) | $41.99 | 82306 | | [Rheumatoid Factor (RF)](https://www.test-well.com/tests/rheumatoid-factor) | 1 (Rheumatoid Factor) | $21.99 | 86431 | | [Rheumatoid Arthritis Antibody Test (Anti-CCP)](https://www.test-well.com/tests/anti-ccp-antibody) | 1 (Anti-CCP Antibodies) | $32.99 | 86200 | | [CBC with Differential](https://www.test-well.com/tests/cbc-with-differential) | 14 (WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, …) | $21.99 | 85025 | | [Comprehensive Metabolic Panel](https://www.test-well.com/tests/comprehensive-metabolic-panel) | 14 (Glucose, BUN, Creatinine, Sodium, Potassium, Chloride, …) | $22.99 | 80053 | ## Price by lab | Lab | Panel price | All-in (with $6 fee) | Notes | | --- | --- | --- | --- | | Quest Diagnostics | $159.99 | $165.99 | Choose at checkout | | Labcorp | $159.99 | $165.99 | Choose at checkout | ## How much does a Autoimmune Advanced Panel cost? A Autoimmune Advanced Panel costs $159.99 at TestWell — $165.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible. | Where you order | Price | One test, all-in | Notes | | --- | --- | --- | --- | | TestWell (drawn at Quest or Labcorp) | $159.99 | $165.99 | Includes the one $6 lab processing fee, charged once per order | ## How do you prepare? No fasting required. No special preparation needed. ## Related conditions - Systemic lupus erythematosus (M32.9) - ANCA-associated vasculitis (M31.7) - Mixed connective tissue disease (M35.1) - Rheumatoid arthritis (M06.9) ## Common questions about the Autoimmune Advanced Panel ### What's included in the Autoimmune Advanced Panel? [ANA Screen](https://www.test-well.com/tests/ana-screen), anti-dsDNA (lupus-specific), anti-Smith (lupus-specific), P-ANCA + C-ANCA (vasculitis), [Rheumatoid Factor](https://www.test-well.com/tests/rheumatoid-factor), [Anti-CCP](https://www.test-well.com/tests/anti-ccp-antibody), Complement C3 + C4 (immune complex disease), ESR / [sed rate](https://www.test-well.com/tests/sed-rate), [hs-CRP](https://www.test-well.com/tests/hs-crp). 10+ tests for disease-specific diagnosis. ### How is this different from the basic Autoimmune Panel? [Autoimmune Panel](https://www.test-well.com/tests/autoimmune-panel) at $130 is screening (5 tests: ANA, RF, anti-CCP, hs-CRP, ESR). Autoimmune Advanced at $160 adds disease-specific antibodies (dsDNA, Smith for lupus; ANCA for vasculitis) and complement levels (active immune complex disease marker). Use Advanced when basic panel is positive and you need a specific diagnosis. ### What do dsDNA and Smith antibodies tell me? Both are highly specific for systemic lupus erythematosus (SLE). Positive anti-dsDNA combined with positive ANA = SLE in most cases (>95% specificity). Positive anti-Smith = SLE definitively (very high specificity, lower sensitivity). Together they confirm or rule out lupus when ANA is positive. ### What does ANCA test for? ANCA antibodies suggest small-vessel vasculitis. C-ANCA pattern with anti-PR3 = Granulomatosis with Polyangiitis (formerly Wegener's). P-ANCA pattern with anti-MPO = Microscopic Polyangiitis or Eosinophilic Granulomatosis (Churg-Strauss). Both are urgent diagnoses requiring nephrology + rheumatology involvement. ### How much does the Autoimmune Advanced Panel cost without insurance? On TestWell, the Autoimmune Advanced Panel is $159.99. Ordering the same tests separately would be about $250. Quest Direct lists comparable bundles at $350, walk-in hospital labs typically bill $700-1100 without insurance. ### Do I need to fast? No fasting required. Avoid intense exercise for 24 hours before draw — [hs-CRP](https://www.test-well.com/tests/hs-crp) and ESR can be transiently elevated by muscle inflammation. ### Should I order this first or after the basic Autoimmune Panel? Order [Autoimmune Panel](https://www.test-well.com/tests/autoimmune-panel) first for unexplained symptoms. Move to Autoimmune Advanced when basic panel is positive (especially ANA) and you need a specific disease diagnosis. Ordering Advanced first is reasonable only with strong clinical suspicion of lupus or vasculitis. ## How to order 1. Add to cart: https://www.test-well.com/cart?add=autoimmune-advanced-panel&utm_source=ai_agent&utm_medium=markdown 2. Create an account or sign in, confirm your state and preferred lab, pay by card, HSA or FSA. 3. A licensed physician authorizes the order (usually within minutes); the requisition arrives by email. 4. One draw at any Quest Diagnostics, Labcorp patient service center covers every test in the panel. 5. Results post to your TestWell portal in 3–5 business days. ## Related - [Autoimmune Panel](https://www.test-well.com/tests/autoimmune-panel) — 5 tests · $129.99 - [Autoimmune Screening Panel](https://www.test-well.com/tests/autoimmune-screening-panel) — 4 tests · $86.99 - [Inflammation Panel](https://www.test-well.com/tests/inflammation-panel) — 7 tests · $119.99 - [All Inflammation & Autoimmune tests](https://www.test-well.com/tests/category/inflammation-autoimmune) - [Full test directory](https://www.test-well.com/tests/directory) --- Medically reviewed by Youmna DiStefano, MD (Medical Reviewer, TestWell); last reviewed 2026-09-14. Review policy: https://www.test-well.com/reviewers/youmna-distefano-md Canonical page: https://www.test-well.com/tests/autoimmune-advanced-panel Machine-readable catalog: https://www.test-well.com/api/catalog.json · MCP server: https://www.test-well.com/mcp · Overview for agents: https://www.test-well.com/llms.txt Prices are cash-pay, in USD, and include physician authorization; every order adds one flat $6 lab processing fee. Educational content is not a diagnosis — discuss results with a clinician.