--- title: ApoE Genotype (Cardiovascular Risk) Test type: test id: apoe-cardio url: "https://www.test-well.com/tests/apoe-genotype-cardio" price_usd: 133.99 lab_fee_usd: 6 all_in_usd: 139.99 category: Heart Health sample: Blood draw fasting_required: false results_in: "5–7 business days" labs: - Quest - Labcorp orderable: true reviewed_at: 2026-09-14 order_url: "https://www.test-well.com/cart?add=apoe-genotype-cardio&utm_source=ai_agent&utm_medium=markdown" --- # ApoE Genotype (Cardiovascular Risk) Test > Identifies your ApoE genotype (E2, E3, E4) to assess genetic cardiovascular and cholesterol risk, measured from a standard blood draw. At TestWell it costs $133.99 plus a $6 lab fee, needs no fasting, and results post in 5–7 business days. Physician-authorized with no doctor's visit or insurance needed; draw at Quest or Labcorp. ## Key facts | Fact | Value | | --- | --- | | Price | $133.99 + $6 lab processing fee per order ($139.99 all-in for this test alone) | | Sample | Blood draw | | Fasting | Not required | | Results | 5–7 business days | | Labs | Quest Diagnostics, Labcorp | | Biomarkers measured | 1 | | Physician authorization | Included — no doctor's visit, referral or insurance needed | | Payment | Card, HSA or FSA; cash-pay only (no insurance billing) | ## What does the ApoE Genotype (Cardiovascular Risk) test tell you? Identifies your ApoE genotype (E2, E3, E4) to assess genetic cardiovascular and cholesterol risk. Apolipoprotein E (ApoE) is a protein involved in cholesterol transport and metabolism. The three common variants — E2, E3, and E4 — influence how your body processes dietary fat and cholesterol. The E4 variant is associated with higher LDL cholesterol, increased cardiovascular risk, and a stronger response to dietary saturated fat. The E2 variant is associated with lower LDL but can increase triglycerides. Knowing your ApoE genotype helps personalize dietary and lifestyle recommendations for heart health and can inform statin therapy decisions. **Clinical use:** ApoE genotype — identifies which of three E2/E3/E4 alleles you carry. ApoE4 carriers have a 2-3× lifetime risk of coronary heart disease and Alzheimer's; ApoE2 carriers have lower CHD risk but higher type III hyperlipoproteinemia risk. ## Who should order it? Anyone with strong family history of early heart disease or Alzheimer's, established hyperlipidemia not responding to statins, or planning a precision-medicine cardiovascular prevention strategy. ## Biomarkers measured - ApoE Genotype ## Price by lab | Lab | Test price | All-in (with $6 fee) | Notes | | --- | --- | --- | --- | | Quest Diagnostics | $133.99 | $139.99 | Choose at checkout; walk-in patient service centers nationwide (not NY/NJ) | | Labcorp | $133.99 | $139.99 | Choose at checkout; walk-in patient service centers nationwide (not NY/NJ) | Rhode Island is not served. Prices are identical online and in the lab; no draw fee or physician fee is added. ## How much does a ApoE Genotype (Cardiovascular Risk) test cost? A ApoE Genotype (Cardiovascular Risk) test costs $133.99 at TestWell — $139.99 all-in when ordered alone, because the $6 lab processing fee is charged once per order, with no draw fee or physician fee added. Hospital outpatient labs typically bill around $500.00 self-pay for the same test, and often more. With insurance, what you pay depends on your deductible and your plan's negotiated rate; TestWell's price is fixed before the draw and is HSA/FSA-eligible. | Where you order | Price | One test, all-in | Notes | | --- | --- | --- | --- | | TestWell (drawn at Quest or Labcorp) | $133.99 | $139.99 | Includes the one $6 lab processing fee, charged once per order | | Hospital outpatient lab, self-pay (typical) | $500.00 | $500.00 | Reference figure; hospital charges vary widely by facility and are often higher | Lab test codes: Quest test code 90649 · Labcorp test no. 503935. ## How do you prepare? No fasting or special preparation required. ## Related conditions - Familial hyperlipidemia (E78.01) - [Cardiovascular disease risk](https://www.test-well.com/conditions/heart-disease-risk) - Alzheimer's disease (familial risk) (G30.0) - Type III hyperlipoproteinemia (E78.2) ## Common questions about the ApoE Genotype (Cardiovascular Risk) test ### What does it mean to have ApoE4? Roughly 25% of people carry one ApoE4 allele (E3/E4); 2-3% carry two (E4/E4). One copy: ~2-3× heart disease risk, ~3× Alzheimer's risk. Two copies: ~5× heart disease, ~12-15× Alzheimer's. Lifestyle and statin therapy substantially mitigate risk — knowing the result enables proactive prevention. ### How much does an ApoE genotype test cost? TestWell charges $133.99 — vs $199 at Quest Direct and $300-$700 at genetics or cardiology clinics. One-time test, result is permanent. ### Do I need to fast? No fasting required. ### What's the CPT code? 81401 (ApoE genotype). HSA/FSA eligible. ### Should I get this test if I have a family history of Alzheimer's? Discuss with a clinician first — there's no cure for Alzheimer's, so the result can produce psychological harm without changing treatment. Some carriers want the information to plan; others don't. Genetic counseling is recommended before testing for Alzheimer's risk. ## How to order 1. Add to cart: https://www.test-well.com/cart?add=apoe-genotype-cardio&utm_source=ai_agent&utm_medium=markdown 2. Create an account or sign in, confirm your state and preferred lab, pay by card, HSA or FSA. 3. A licensed physician authorizes the order (usually within minutes); the requisition arrives by email. 4. Walk into any Quest Diagnostics, Labcorp patient service center — no appointment needed at most sites. 5. Results post to your TestWell portal in 5–7 business days with reference ranges and flags. ## Related - [Genetic Risk Panel](https://www.test-well.com/tests/genetic-risk-panel) — 3 tests · $299.99 - [Advanced Cholesterol Particle Test (NMR)](https://www.test-well.com/tests/nmr-lipoprofile) — $70.99 - [ApoB — Heart Attack Risk Predictor](https://www.test-well.com/tests/apolipoprotein-b) — $30.99 - [Fibrinogen Activity](https://www.test-well.com/tests/fibrinogen-test) — $22.99 - [Homocysteine](https://www.test-well.com/tests/homocysteine) — $27.99 - [Lp(a) Hereditary Heart Risk Test](https://www.test-well.com/tests/lipoprotein-a) — $34.99 - [All Heart Health tests](https://www.test-well.com/tests/category/heart-health) - [Full test directory](https://www.test-well.com/tests/directory) --- Medically reviewed by Youmna DiStefano, MD (Medical Reviewer, TestWell); last reviewed 2026-09-14. Review policy: https://www.test-well.com/reviewers/youmna-distefano-md Canonical page: https://www.test-well.com/tests/apoe-genotype-cardio Machine-readable catalog: https://www.test-well.com/api/catalog.json · MCP server: https://www.test-well.com/mcp · Overview for agents: https://www.test-well.com/llms.txt Prices are cash-pay, in USD, and include physician authorization; every order adds one flat $6 lab processing fee. Educational content is not a diagnosis — discuss results with a clinician.