--- title: Estradiol Test type: biomarker url: "https://www.test-well.com/biomarkers/estradiol" also_known_as: - estradiol - e2 category: Hormones units: - pg/mL order_price_usd: 35.99 order_item: Estradiol (E2) order_url: "https://www.test-well.com/tests/estradiol" reviewed_at: 2026-09-06 --- # Estradiol > Estradiol is measured with a standard blood draw; no fasting is needed. A typical reference range is 10.0 – 40.0 pg/mL (male, age 18+; more bands below). At TestWell it's $35.99 all-in as Estradiol (E2), results in 1–3 business days, drawn at Quest or Labcorp. An out-of-range result is a prompt to look closer, not a diagnosis. Also known as: estradiol, e2. ## Key facts | Fact | Value | | --- | --- | | Units | pg/mL | | Sample | Blood draw | | Fasting | Not required | | Results | 1–3 business days | | Price | $35.99 | | Labs | Quest or Labcorp · BioReference in NY/NJ | ## What does Estradiol measure? The primary form of estrogen. Levels vary widely with menstrual cycle, age, and reproductive stage. ## What is the normal range for Estradiol? | Population | Reference range | | --- | --- | | Male, age 18+ | 10.0 – 40.0 pg/mL | | Female, age 18+, varies by cycle phase | 15.0 – 350 pg/mL | Reference intervals differ slightly between labs; the range printed on your report is the one to interpret against. Ranges are usually set so 95% of healthy people fall inside them. ## What does a high Estradiol mean? In women who cycle, a 'high' estradiol is often just mid-cycle — levels peak before ovulation — so cycle day is essential. Persistently high levels can come from estrogen therapy, ovarian cysts or tumors, obesity (fat tissue makes estrogen) and liver disease. In men, high estradiol usually accompanies testosterone therapy, obesity or liver disease and can cause breast tenderness. ### Common causes of high Estradiol 1. Normal pre-ovulatory peak (cycle days ~10–14) or pregnancy 2. Estrogen-containing medication or hormone therapy 3. Obesity — aromatization of androgens to estrogen 4. Men: testosterone therapy, obesity, liver disease 5. Ovarian cysts or estrogen-producing tumors (rare); testicular or adrenal tumors in men (rare) 6. Liver disease reducing estrogen clearance ### Symptoms that go with high Estradiol - Women: breast tenderness, bloating, heavy periods, mood changes - Men: breast enlargement or tenderness, reduced libido, water retention ### What clinicians usually check next - Repeat on cycle days 2–5 in cycling women - Men: total testosterone, SHBG, liver panel; review therapy dose - Pelvic ultrasound if persistently high without explanation - Note that standard estradiol assays are imprecise at low levels — a sensitive (LC-MS) assay is used for men and postmenopausal women Follow-up tests at TestWell: [SHBG (Sex Hormone Binding Globulin)](https://www.test-well.com/tests/shbg-sex-hormone-binding-globulin) ($34.99). **What does high estradiol mean for a man?** Usually that testosterone is being converted to estrogen — common with obesity or on testosterone therapy. It's managed by the prescriber; self-treating with aromatase inhibitors carries bone and lipid risks. ## What does a low Estradiol mean? Low estradiol is expected after menopause and early in the menstrual cycle, so context decides its meaning. In a woman of reproductive age with missed periods it points to ovarian insufficiency, low body weight or over-exercise, high prolactin, or a pituitary problem. In men, low estradiol on testosterone-lowering therapy or aromatase inhibitors contributes to bone loss and joint pain. ### Common causes of low Estradiol 1. Menopause or perimenopause 2. Normal early follicular phase (cycle days 2–5) 3. Functional hypothalamic amenorrhea: low body weight, eating disorders, heavy exercise, stress 4. Primary ovarian insufficiency, Turner syndrome 5. High prolactin, pituitary disorders 6. Men: aromatase inhibitors, hypogonadism ### Symptoms that go with low Estradiol - Hot flashes, night sweats, vaginal dryness - Irregular or absent periods - Low mood, poor sleep, joint aches - Bone loss over time ### What clinicians usually check next - FSH and LH — high FSH points to the ovaries; low or normal points upstream - Prolactin and TSH - Pregnancy test in anyone who could be pregnant - Bone density assessment if low estradiol is prolonged Follow-up tests at TestWell: [TSH (Thyroid Stimulating Hormone)](https://www.test-well.com/tests/tsh) ($26.99), [TSH + Free T4](https://www.test-well.com/tests/tsh-with-free-t4) ($27.99), [FSH (Follicle Stimulating Hormone)](https://www.test-well.com/tests/fsh) ($29.99), [Pregnancy Test (Quantitative hCG)](https://www.test-well.com/tests/hcg-quantitative) ($26.99), [LH (Luteinizing Hormone)](https://www.test-well.com/tests/luteinizing-hormone) ($36.99), [Prolactin](https://www.test-well.com/tests/prolactin) ($39.99). **Does low estradiol confirm menopause?** A low estradiol with a high FSH in a woman of the right age, with 12 months without periods, fits menopause. Levels swing during perimenopause, so a single value isn't definitive. ## How do you get tested for Estradiol? | Order | Type | Price | Includes | | --- | --- | --- | --- | | [Estradiol (E2)](https://www.test-well.com/tests/estradiol) | Single test | $35.99 | This marker | | [Erectile Dysfunction Panel](https://www.test-well.com/tests/erectile-dysfunction-panel) | Panel | $114.99 | 7 tests | | [Women's Fertility Essentials](https://www.test-well.com/tests/female-fertility-panel) | Panel | $119.99 | 5 tests | | [TRT Quarterly Panel](https://www.test-well.com/tests/trt-quarterly-panel) | Panel | $179.00 | 11 tests | | [Menopause Assessment Panel](https://www.test-well.com/tests/menopause-panel) | Panel | $179.99 | 8 tests | ## Quest vs Labcorp vs BioReference | Lab | Available | Price | Notes | | --- | --- | --- | --- | | Quest Diagnostics | Yes | $35.99 | Choose Quest at checkout; walk-in patient service centers in every state TestWell serves outside NY and NJ. | | Labcorp | Yes | $56.99 | Choose Labcorp at checkout; walk-in patient service centers in every state TestWell serves outside NY and NJ. | | BioReference (NY & NJ) | Yes | $42.99 | New York and New Jersey orders route here automatically — state rules keep Quest and Labcorp from accepting self-ordered draws. | ## Common questions about Estradiol ### Do I need a doctor's order to test my estradiol? No. TestWell's licensed physician network reviews and approves your order — usually within minutes. You can place an order online without an in-person visit or a referral from your own doctor. ### How long does it take to get Estradiol results? Most Estradiol results are available in 1–3 business days after your specimen arrives at the lab. You'll get an email the moment your results are ready, with everything viewable in your TestWell portal. ### How much does a Estradiol test cost? Our Estradiol (E2) starts at $35.99. That's the all-in price — no copays, no insurance hoops, no surprise bills. HSA and FSA cards are accepted. ### Do I need to fast before my Estradiol test? Fasting is not required for the Estradiol test. You can have your blood drawn any time of day. ### Which lab will process my Estradiol test? Your test will be processed by Quest Diagnostics, Labcorp, or BioReference depending on which is closest to you and which lab carries the test. All three are CLIA-certified and trusted by hospitals nationwide. You'll choose your lab during checkout from 4,000+ locations. ## Sources - [Mayo Clinic Labs](https://www.mayocliniclabs.com/test-catalog/overview/81816) - [MedlinePlus (NIH) — Estrogen Levels Test](https://medlineplus.gov/lab-tests/estrogen-levels-test/) ## Related biomarkers - [Total Testosterone](https://www.test-well.com/biomarkers/total-testosterone) - [Free Testosterone](https://www.test-well.com/biomarkers/free-testosterone) - [SHBG](https://www.test-well.com/biomarkers/shbg) - [Cortisol AM](https://www.test-well.com/biomarkers/cortisol-am) - [DHEA-S](https://www.test-well.com/biomarkers/dhea-s) - [FSH](https://www.test-well.com/biomarkers/fsh) - [Reference range lookup tool](https://www.test-well.com/tools/reference-range-lookup) - [Lab unit converter](https://www.test-well.com/tools/lab-unit-converter) - [All biomarkers](https://www.test-well.com/biomarkers) --- Medically reviewed by Youmna DiStefano, MD (Medical Reviewer, TestWell); last reviewed 2026-09-06. Review policy: https://www.test-well.com/reviewers/youmna-distefano-md Canonical page: https://www.test-well.com/biomarkers/estradiol Machine-readable catalog: https://www.test-well.com/api/catalog.json · MCP server: https://www.test-well.com/mcp · Overview for agents: https://www.test-well.com/llms.txt Prices are cash-pay, in USD, and include physician authorization; every order adds one flat $6 lab processing fee. Educational content is not a diagnosis — discuss results with a clinician.